Comparing the diagnostic value of bronchoalveolar lavage fluid galactomannan, serum galactomannanan, and serum 1,3-β-d-glucan in non-neutropenic respiratory disease patients with invasive pulmonary aspergillosis

The incidence of invasive pulmonary aspergillosis (IPA) is increasing higher in non-neutropenic patients. This study aimed to assess the diagnostic performance of bronchoalveolar lavage fluid (BALF). Galactomannan (GM), serum GM, and 1,3-β-d-glucan (BDG) in non-neutropenic respiratory disease patien...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-04, Vol.100 (14), p.e25233-e25233
Main Authors: Dai, Zhang, Cai, Minjing, Yao, Yihui, Zhu, Jianhui, Lin, Lingqing, Fang, Lili, Li, Zhimeng, Yi, Huochun, Chen, Bo, Liang, Xianming
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - analysis
Bronchoalveolar Lavage Fluid
Female
Galactose - analogs & derivatives
Glucans - blood
Humans
Invasive Pulmonary Aspergillosis - diagnosis
Male
Mannans - blood
Middle Aged
Observational Study
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Summary:The incidence of invasive pulmonary aspergillosis (IPA) is increasing higher in non-neutropenic patients. This study aimed to assess the diagnostic performance of bronchoalveolar lavage fluid (BALF). Galactomannan (GM), serum GM, and 1,3-β-d-glucan (BDG) in non-neutropenic respiratory disease patients with IPA.A total of 333 non-neutropenic patients suspected IPA were recruited from Xiamen University Zhong Shan hospital between January 2016 and February 2019. One, 33, and 92 cases were diagnosed with proven, and possible IPA.BALF and serum GM were both elevated in the possible IPA group and the probable/proven IPA group (p 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000025233