Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary Intake

The incidence of thyroid cancer continues to increase steadily, and this increasing incidence cannot be attributed solely to the overdiagnosis of microcarcinoma or technical advancements in detection methods and may also depend on environmental and genetic factors. However, the impacts and interacti...

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Bibliographic Details
Published in:Cancers 2021-03, Vol.13 (7), p.1510
Main Authors: Song, Sang Shin, Huang, ShaoKai, Park, Sunmin
Format: Article
Language:English
Subjects:
Blood
Cell differentiation
Dietary intake
Environmental factors
Estrogens
Etiology
Food
Gene expression
Genetic diversity
Genetic factors
Genetic testing
Genome-wide association studies
Genomes
Inflammation
Iodine
Meat
Mutation
Polymorphism
Principal components analysis
Questionnaires
Radiation
Risk factors
Seaweeds
Single-nucleotide polymorphism
Thyroid cancer
Tumorigenesis
Tumors
Womens health
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Summary:The incidence of thyroid cancer continues to increase steadily, and this increasing incidence cannot be attributed solely to the overdiagnosis of microcarcinoma or technical advancements in detection methods and may also depend on environmental and genetic factors. However, the impacts and interactions of genetic and environmental factors remain controversial, and they may differ in Eastern and Western countries. The study's purpose was to identify single nucleotide polymorphisms of genes related to cell differentiation and inflammation to influence thyroid cancer incidence and determine interactions with lifestyles in a large city hospital-based cohort. Genetic variants were selected by genome-wide association study with thyroid cancer participants (case; = 495) and controls without cancers ( = 56,439). SNPs having gene-gene interactions were selected by generalized multifactor dimensionality reduction. Polygenic risk scores (PRSs) were generated by summing the number of selected SNP risk alleles. PRSs of the best model included 6 SNPs, that is, _rs6759952, _rs13059137, _rs7834206, _rs72616195, _rs1369535, and _rs11175834. Participants with a high-PRS had a higher thyroid cancer risk by 3.9-fold than those with a low-PRS. The following variables were related to an increased thyroid cancer risk; female (OR = 4.21), high white blood cell count (OR = 4.03), and high energy (OR = 7.00), low alcohol (OR = 4.11), and high seaweed (OR = 4.02) intakes. These variables also interacted with PRS to influence thyroid cancer risk. Meat/noodle diet patterns interacted with PRSs to increase thyroid cancer risk ( = 0.0023). In conclusion, women with a high-PRS associated with cell differentiation and inflammation were at an elevated thyroid cancer risk. Daily energy, seaweeds, and alcohol intake interacted with PRS for thyroid cancer risk. These results could be applied to personalized nutrition plans to reduce the risk of thyroid cancer.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13071510