Neutrophil-to-lymphocyte ratio as a predictive marker for severe pediatric sepsis

Although neutrophil-to-lymphocyte ratio (NLR) has been extensively studied in several diseases, its role in pediatric sepsis remains unclear. Our study aimed to assess the predictive significance of NLR for severe pediatric sepsis in the pediatric intensive care unit (PICU). We retrospectively recru...

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Bibliographic Details
Published in:Translational pediatrics 2021-03, Vol.10 (3), p.657-665
Main Authors: Zhong, Xi, Ma, Aijia, Zhang, Zhongwei, Liu, Yong, Liang, Guopeng
Format: Article
Language:English
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Summary:Although neutrophil-to-lymphocyte ratio (NLR) has been extensively studied in several diseases, its role in pediatric sepsis remains unclear. Our study aimed to assess the predictive significance of NLR for severe pediatric sepsis in the pediatric intensive care unit (PICU). We retrospectively recruited critically ill children in the PICU with severe pediatric sepsis from January 2019 to January 2020 in West China Hospital of Sichuan University. Univariate and multivariable logistic regression analysis was used to assess the risk factors of severe pediatric sepsis. Receiver operating characteristic (ROC) curves were plotted for the comparison of the prediction significance of NLR. Overall, 202 patients (severe sepsis 45; non-severe sepsis 157) were included. In the severe sepsis group, the levels of NLR (P
ISSN:2224-4344
2224-4336
2224-4344
DOI:10.21037/tp-21-47