Musical practice and BDNF plasma levels as a potential marker of synaptic plasticity: an instrument of rehabilitative processes

Background and objectives The aim of the study was to investigate the influence of musical practice on brain plasticity. BDNF (brain-derived neurotrophic factor) is a neurotrophin involved in neuroplasticity and synaptic function. Materials and methods We recruited 48 healthy subjects of equal age a...

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Bibliographic Details
Published in:Neurological sciences 2021-05, Vol.42 (5), p.1861-1867
Main Authors: Minutillo, Alessandro, Panza, Gabriele, Mauri, Massimo Carlo
Format: Article
Language:English
Subjects:
Autism
Biomarkers
Brain-Derived Neurotrophic Factor
Humans
Medicine
Medicine & Public Health
Mental disorders
Music
Neurology
Neuronal Plasticity
Neuroplasticity
Neuroradiology
Neurosciences
Neurosurgery
Original
Original Article
Oxytocin
Plasma levels
Psychiatry
Signal Transduction
Statistical analysis
Synaptic plasticity
Vasopressin
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Summary:Background and objectives The aim of the study was to investigate the influence of musical practice on brain plasticity. BDNF (brain-derived neurotrophic factor) is a neurotrophin involved in neuroplasticity and synaptic function. Materials and methods We recruited 48 healthy subjects of equal age and sex (21 musicians and 27 non-musicians). All subjects were administered the AQ (Autism-Spectrum Questionnaire) and plasma levels (PLs) of BDNF, oxytocin (OT), and vasopressin (VP) were measured in the blood sample of every participant. Results. The difference between BDNF PLs in the two groups was found to be statistically significant ( t  = − 2.214, p  = 0.03). Furthermore, oxytocin (OT) PLs and musical practice were found to be independent positive predictors of BDNF PLs ( p  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-020-04715-9