Double-layered Nanofibrous Patch for Prevention of Anastomotic Leakage and Peritoneal Adhesions, Experimental Study

Anastomotic leakage is a feared complication in colorectal surgery. Postoperative peritoneal adhesions can also cause life-threatening conditions. Nanofibrous materials showed their pro-healing properties in various studies. The aim of the study was to evaluate the impact of double-layered nanofibro...

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Published in:In vivo (Athens) 2021-03, Vol.35 (2), p.731-741
Main Authors: Rosendorf, Jachym, Klicova, Marketa, Cervenkova, Lenka, Palek, Richard, Horakova, Jana, Klapstova, Andrea, Hosek, Petr, Moulisova, Vladimira, Bednar, Lukas, Tegl, Vaclav, Brzon, Ondrej, Tonar, Zbynek, Treska, Vladislav, Lukas, David, Liska, Vaclav
Format: Article
Language:English
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Summary:Anastomotic leakage is a feared complication in colorectal surgery. Postoperative peritoneal adhesions can also cause life-threatening conditions. Nanofibrous materials showed their pro-healing properties in various studies. The aim of the study was to evaluate the impact of double-layered nanofibrous materials on anastomotic healing and peritoneal adhesions formation. Two versions of double-layered materials from polycaprolactone and polyvinyl alcohol were applied on defective anastomosis on the small intestine of healthy pigs. The control group remained with uncovered defect. Tissue specimens were subjected to histological analysis and adhesion scoring after 3 weeks of observation. The wound healing was inferior in the experimental groups, however, no anastomotic leakage was observed and the applied material always kept covering the defect. The extent of adhesions was larger in the experimental groups. Nanofibrous materials may prevent anastomotic leakage but delay healing.
ISSN:0258-851X
1791-7549
DOI:10.21873/INVIVO.12314