Prognostic impact of sarcopenia in cirrhotic patients stratified by different severity of portal hypertension

Background and Aims Portal hypertension (PH) and sarcopenia are common in patients with advanced chronic liver disease (ACLD). However, the interaction between PH and sarcopenia and their specific and independent impact on prognosis and mortality has yet to be systematically investigated in patients...

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Bibliographic Details
Published in:Liver international 2021-04, Vol.41 (4), p.799-809
Main Authors: Paternostro, Rafael, Bardach, Constanze, Hofer, Benedikt S., Scheiner, Bernhard, Schwabl, Philipp, Asenbaum, Ulrika, Ba‐Ssalamah, Ahmed, Scharitzer, Martina, Bucscis, Theresa, Simbrunner, Benedikt, Bauer, David, Trauner, Michael, Mandorfer, Mattias, Reiberger, Thomas, Lampichler, Katharina
Format: Article
Language:English
Subjects:
advanced chronic liver disease
cirrhosis
Cirrhosis, Liver Failure and Transplantation
Computed tomography
Confidence intervals
hepatic venous pressure gradient
Hypertension
Liver
Liver diseases
Magnetic resonance imaging
Men
Mercury
Mortality
Multivariate analysis
muscle wasting
Muscles
Original
portal hypertension
Psoas muscle
Risk analysis
Risk factors
Sarcopenia
Vertebrae
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Summary:Background and Aims Portal hypertension (PH) and sarcopenia are common in patients with advanced chronic liver disease (ACLD). However, the interaction between PH and sarcopenia and their specific and independent impact on prognosis and mortality has yet to be systematically investigated in patients with ACLD. Methods Consecutive patients with ACLD and hepatic venous pressure gradient (HVPG) ≥10 mm Hg with available CT/MRI imaging were included. Sarcopenia was defined by transversal psoas muscle thickness (TPMT) at
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.14758