Novel approaches for vaccine development

Vaccines are critical tools for maintaining global health. Traditional vaccine technologies have been used across a wide range of bacterial and viral pathogens, yet there are a number of examples where they have not been successful, such as for persistent infections, rapidly evolving pathogens with...

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Bibliographic Details
Published in:Cell 2021-03, Vol.184 (6), p.1589-1603
Main Authors: Gebre, Makda S., Brito, Luis A., Tostanoski, Lisa H., Edwards, Darin K., Carfi, Andrea, Barouch, Dan H.
Format: Article
Language:English
Subjects:
Adenoviridae - genetics
Animals
Antigens, Viral - genetics
Biocompatible Materials
COVID-19 - prevention & control
COVID-19 - virology
COVID-19 Vaccines - immunology
COVID-19 Vaccines - therapeutic use
Drug Delivery Systems - methods
Genetic Vectors - immunology
Humans
Immunogenicity, Vaccine
Liposomes
mRNA Vaccines
Nanoparticles
RNA, Messenger - chemical synthesis
RNA, Messenger - immunology
SARS-CoV-2 - immunology
Vaccines, Synthetic - immunology
Vaccines, Synthetic - therapeutic use
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Summary:Vaccines are critical tools for maintaining global health. Traditional vaccine technologies have been used across a wide range of bacterial and viral pathogens, yet there are a number of examples where they have not been successful, such as for persistent infections, rapidly evolving pathogens with high sequence variability, complex viral antigens, and emerging pathogens. Novel technologies such as nucleic acid and viral vector vaccines offer the potential to revolutionize vaccine development as they are well-suited to address existing technology limitations. In this review, we discuss the current state of RNA vaccines, recombinant adenovirus vector-based vaccines, and advances from biomaterials and engineering that address these important public health challenges. Vaccines play a critical role in global health, and Gebre et al. review the current state of three vaccine development platforms (mRNA vaccines, vector-based vaccines, and materials science approaches to vaccination).
ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2021.02.030