Medetomidine-midazolam sedation in sheep

Seven sheep were sedated 3 times: with medetomidine (15 micrograms kg-1), with midazolam (0.1 mg kg-1) and with a combination of the drugs. All drugs were administered intravenously. Heart and respiratory rates were measured. Arterial blood samples were collected, and PaO2, PaCO2, pH, haemoglobin co...

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Bibliographic Details
Published in:Acta veterinaria scandinavica 1998-01, Vol.39 (1), p.127-134
Main Authors: Raekallio, M, Tulamo, R.-M, Valtamo, T. (Helsinki Univ. (Finland). Dept. of Clinical Sciences)
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - drug effects
Carbon Dioxide - blood
Drug Interactions
EFECTOS SECUNDARIOS
EFFET SECONDAIRE
FARMACOLOGIA
Female
Heart Arrest - chemically induced
Heart Rate - drug effects
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - pharmacology
Imidazoles - administration & dosage
Imidazoles - pharmacology
Injections, Intravenous
Medetomidine
MEDICAMENT NEUROTROPE
MEDICAMENTOS NEUROTROPICOS
Midazolam - administration & dosage
Midazolam - pharmacology
NEUROTROPIC DRUGS
OVIN
OVINOS
Oxygen - blood
Oxyhemoglobins - metabolism
Partial Pressure
PHARMACOLOGIE
PHARMACOLOGY
Resuscitation
SHEEP
SIDE EFFECTS
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Summary:Seven sheep were sedated 3 times: with medetomidine (15 micrograms kg-1), with midazolam (0.1 mg kg-1) and with a combination of the drugs. All drugs were administered intravenously. Heart and respiratory rates were measured. Arterial blood samples were collected, and PaO2, PaCO2, pH, haemoglobin concentration and saturation, and base excess were determined. Systolic and mean arterial pressures were recorded before and after the treatment with medetomidine-midazolam. Midazolam increased the time of recumbency induced by medetomidine. After administration of midazolam alone, 4 of the 7 sheep were sedated and the other 3 were excited. Heart rate decreased after both medetomidine and medetomidine-midazolam. One sheep suffered a cardiac arrest after medetomidine-midazolam injection, and it required resuscitation. PaO2 and haemoglobin oxygen saturation decreased after medetomidine, and medetomidine-midazolam caused a marked hypoxaemia. PaCO2 increased after medetomidine, both alone and combined with midazolam, but arterial pH was within the reference values after all drug administrations. Systolic and mean arterial pressures decreased after medetomidine-midazolam. This study indicates that though in sheep midazolam potentiates the sedative effect of medetomidine, the combination of medetomidine and midazolam also reduces the in PaO2 and haemoglobin oxygen saturation more than medetomidine alone. The results indicate that a medetomidine-midazolam combination is unsafe for sheep at the doses studied.
ISSN:0044-605X
1751-0147
1751-0147
DOI:10.1186/BF03547814