FlowCell-enriched circulating tumor cells as a predictor of lung cancer metastasis

Lung cancer is the most fetal malignancy due to the high rate of metastasis and recurrence after treatment. A considerable number of patients with early-stage lung cancer relapse due to overlooked distant metastasis. Circulating tumor cells (CTCs) are tumor cells in blood circulation that originated...

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Bibliographic Details
Published in:Human cell : official journal of Human Cell Research Society 2021-05, Vol.34 (3), p.945-951
Main Authors: Lu, Yan, Zheng, Yushuang, Wang, Yuhong, Gu, Dongmei, Zhang, Jun, Liu, Fang, Chen, Kai, Guo, Lingchuan
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Blood circulation
Cell Biology
Fetuses
Gynecology
Life Sciences
Lung cancer
Malignancy
Metastases
Metastasis
Oncology
Reproductive Medicine
Research Article
Stem Cells
Surgery
Tumor cells
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Summary:Lung cancer is the most fetal malignancy due to the high rate of metastasis and recurrence after treatment. A considerable number of patients with early-stage lung cancer relapse due to overlooked distant metastasis. Circulating tumor cells (CTCs) are tumor cells in blood circulation that originated from primary or metastatic sites, and it has been shown that CTCs are critical for metastasis and prognosis in various type of cancers. Here, we employed novel method to capture, isolate and classify CTC with FlowCell system and analyzed the CTCs from a cohort of 302 individuals. Our results illustrated that FlowCell-enriched CTCs effectively differentiated benign and malignant lung tumor and the total CTC counts increased as the tumor developed. More importantly, we showed that CTCs displayed superior sensitivity and specificity to predict lung cancer metastasis in comparison to conventional circulating biomarkers. Taken together, our data suggested CTCs can be used to assist the diagnosis of lung cancer as well as predict lung cancer metastasis. These findings provide an alternative means to screen early-stage metastasis.
ISSN:1749-0774
0914-7470
1749-0774
DOI:10.1007/s13577-021-00500-8