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The evolving metabolic landscape of chromatin biology and epigenetics
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs — which include both nutrient availability as a result of diet and growth factor signalling — are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Rec...
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| Published in: | Nature reviews. Genetics 2020-12, Vol.21 (12), p.737-753 |
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| cites | cdi_FETCH-LOGICAL-c668t-59ce21649d55036cdbde25635ea9c215ad72a64cc28fdcfcd4f6864acb4534e93 |
| container_end_page | 753 |
| container_issue | 12 |
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| container_title | Nature reviews. Genetics |
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| creator | Dai, Ziwei Ramesh, Vijyendra Locasale, Jason W. |
| description | Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs — which include both nutrient availability as a result of diet and growth factor signalling — are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology and pathology. In this Review, we discuss the nature of these molecular networks, highlight their role in mediating cellular responses and explore their modifiability through dietary and pharmacological interventions.
Various cellular metabolites provide the chemical moieties for DNA and histone modifications, resulting in a complex interplay between metabolism and epigenetics. In this Review, Dai, Ramesh and Locasale discuss the metabolic regulation of diverse types of chromatin modifications and the functional consequences of these modifications at the molecular, cellular and organismal levels, as well as influences from diet and microbiota. |
| doi_str_mv | 10.1038/s41576-020-0270-8 |
| format | article |
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Various cellular metabolites provide the chemical moieties for DNA and histone modifications, resulting in a complex interplay between metabolism and epigenetics. In this Review, Dai, Ramesh and Locasale discuss the metabolic regulation of diverse types of chromatin modifications and the functional consequences of these modifications at the molecular, cellular and organismal levels, as well as influences from diet and microbiota.</description><identifier>ISSN: 1471-0056</identifier><identifier>EISSN: 1471-0064</identifier><identifier>DOI: 10.1038/s41576-020-0270-8</identifier><identifier>PMID: 32908249</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/200 ; 631/337/100 ; 631/337/458 ; 631/337/572 ; 631/443/319 ; Agriculture ; Alcohol Drinking ; Animal Genetics and Genomics ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cell research ; Cellular control mechanisms ; Chromatin ; Chromatin - metabolism ; Chromatin - physiology ; Deoxyribonucleic acid ; Diet ; DNA ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Gene Function ; Gene-Environment Interaction ; Genetic aspects ; Health aspects ; Histones ; Histones - metabolism ; Homeostasis ; Human Genetics ; Humans ; Metabolic regulation ; Metabolism ; Metabolites ; Microbiota ; Neoplasms - genetics ; Neoplasms - metabolism ; Nutrient availability ; Nutritional Physiological Phenomena ; Review Article ; RNA - metabolism ; Structure</subject><ispartof>Nature reviews. Genetics, 2020-12, Vol.21 (12), p.737-753</ispartof><rights>Springer Nature Limited 2020</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c668t-59ce21649d55036cdbde25635ea9c215ad72a64cc28fdcfcd4f6864acb4534e93</citedby><cites>FETCH-LOGICAL-c668t-59ce21649d55036cdbde25635ea9c215ad72a64cc28fdcfcd4f6864acb4534e93</cites><orcidid>0000-0002-0858-638X ; 0000-0001-8818-6863 ; 0000-0002-7766-3502</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32908249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, Ziwei</creatorcontrib><creatorcontrib>Ramesh, Vijyendra</creatorcontrib><creatorcontrib>Locasale, Jason W.</creatorcontrib><title>The evolving metabolic landscape of chromatin biology and epigenetics</title><title>Nature reviews. Genetics</title><addtitle>Nat Rev Genet</addtitle><addtitle>Nat Rev Genet</addtitle><description>Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs — which include both nutrient availability as a result of diet and growth factor signalling — are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology and pathology. In this Review, we discuss the nature of these molecular networks, highlight their role in mediating cellular responses and explore their modifiability through dietary and pharmacological interventions.
Various cellular metabolites provide the chemical moieties for DNA and histone modifications, resulting in a complex interplay between metabolism and epigenetics. 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Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology and pathology. In this Review, we discuss the nature of these molecular networks, highlight their role in mediating cellular responses and explore their modifiability through dietary and pharmacological interventions.
Various cellular metabolites provide the chemical moieties for DNA and histone modifications, resulting in a complex interplay between metabolism and epigenetics. In this Review, Dai, Ramesh and Locasale discuss the metabolic regulation of diverse types of chromatin modifications and the functional consequences of these modifications at the molecular, cellular and organismal levels, as well as influences from diet and microbiota.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32908249</pmid><doi>10.1038/s41576-020-0270-8</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-0858-638X</orcidid><orcidid>https://orcid.org/0000-0001-8818-6863</orcidid><orcidid>https://orcid.org/0000-0002-7766-3502</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/208/200 631/337/100 631/337/458 631/337/572 631/443/319 Agriculture Alcohol Drinking Animal Genetics and Genomics Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell research Cellular control mechanisms Chromatin Chromatin - metabolism Chromatin - physiology Deoxyribonucleic acid Diet DNA Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene Function Gene-Environment Interaction Genetic aspects Health aspects Histones Histones - metabolism Homeostasis Human Genetics Humans Metabolic regulation Metabolism Metabolites Microbiota Neoplasms - genetics Neoplasms - metabolism Nutrient availability Nutritional Physiological Phenomena Review Article RNA - metabolism Structure |
| title | The evolving metabolic landscape of chromatin biology and epigenetics |
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