Microarray patches enable the development of skin-targeted vaccines against COVID-19

The COVID-19 pandemic is a serious threat to global health and the global economy. The ongoing race to develop a safe and efficacious vaccine to prevent infection by SARS-CoV-2, the causative agent for COVID-19, highlights the importance of vaccination to combat infectious pathogens. The highly acce...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2021-04, Vol.171, p.164-186
Main Authors: Korkmaz, Emrullah, Balmert, Stephen C., Sumpter, Tina L., Carey, Cara Donahue, Erdos, Geza, Falo, Louis D.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
COVID-19
COVID-19 - immunology
COVID-19 - metabolism
COVID-19 - prevention & control
COVID-19 Vaccines - administration & dosage
COVID-19 Vaccines - immunology
COVID-19 Vaccines - metabolism
Cutaneous immunobiology
Drug Development - methods
Drug Development - trends
Humans
Immunity, Innate - drug effects
Immunity, Innate - physiology
Infectious diseases
Microarray patches
Prophylactic immunization
SARS-CoV-2
SARS-CoV-2 - drug effects
SARS-CoV-2 - immunology
SARS-CoV-2 - metabolism
Skin - drug effects
Skin - immunology
Skin - metabolism
Skin-targeted vaccines
Spike protein
Transdermal Patch - trends
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Summary:The COVID-19 pandemic is a serious threat to global health and the global economy. The ongoing race to develop a safe and efficacious vaccine to prevent infection by SARS-CoV-2, the causative agent for COVID-19, highlights the importance of vaccination to combat infectious pathogens. The highly accessible cutaneous microenvironment is an ideal target for vaccination since the skin harbors a high density of antigen-presenting cells and immune accessory cells with broad innate immune functions. Microarray patches (MAPs) are an attractive intracutaneous biocargo delivery system that enables safe, reproducible, and controlled administration of vaccine components (antigens, with or without adjuvants) to defined skin microenvironments. This review describes the structure of the SARS-CoV-2 virus and relevant antigenic targets for vaccination, summarizes key concepts of skin immunobiology in the context of prophylactic immunization, and presents an overview of MAP-mediated cutaneous vaccine delivery. Concluding remarks on MAP-based skin immunization are provided to contribute to the rational development of safe and effective MAP-delivered vaccines against emerging infectious diseases, including COVID-19. [Display omitted]
ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2021.01.022