Periodontal health related–inflammatory and metabolic profiles of patients with end-stage renal disease: potential strategy for predictive, preventive, and personalized medicine

• Published in: The EPMA journal 2021-06, Vol.12 (2), p.117-128
• Main Authors: Ma, Xiaoxin, Wang, Yongli, Wu, Hongyu, Li, Fei, Feng, Xiping, Xie, Yingxin, Xie, Danshu, Wang, Wenji, Lo, Edward Chin Man, Lu, Haixia
• Format: Article
• Language: English
• Subjects: Biomarkers; Biomedical and Life Sciences; Biomedicine; Cytokines; Kidney diseases; Medicine/Public Health; Metabolism; Metabolites; Precision medicine
• ISSN: 1878-5077; 1878-5085
• DOI: 10.1007/s13167-021-00239-0

Objectives To compare the periodontal health related–inflammatory and metabolic differences between patients with end-stage renal disease (ESRD) and healthy controls (HC), and to identify potential biomarkers in gingival crevicular fluid (GCF) and serum of ESRD patients for predictive, preventive, and personalized medicine (PPPM). Methods Patients with ESRD (ESRD group; n  = 52) and healthy controls (HC group; n  = 44) were recruited. Clinical periodontal parameters were recorded. The differential metabolites in the GCF and serum were identified by liquid chromatography/mass spectrometry (LC/MS). Inflammatory markers including interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and C-reactive protein (CRP) were also assessed. Results In the ESRD group, IL-8 and CRP were significantly higher in GCF, whereas IL-6 and CRP were significantly higher in serum, compared with HC group (all P