Left ventricular circumferential strain and coronary microvascular dysfunction: A report from the Women's Ischemia Syndrome Evaluation Coronary Vascular Dysfunction (WISE-CVD) Project

Women with ischemia but no obstructive coronary artery disease (INOCA) often have coronary microvascular dysfunction (CMD). Left ventricular (LV) circumferential strain (CS) is often lower in INOCA compared to healthy controls; however, it remains unclear whether CS differs between INOCA women with...

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Bibliographic Details
Published in:International journal of cardiology 2021-03, Vol.327, p.25-30
Main Authors: Tamarappoo, Balaji, Samuel, T. Jake, Elboudwarej, Omeed, Thomson, Louise E.J., Aldiwani, Haider, Wei, Janet, Mehta, Puja, Cheng, Susan, Sharif, Behzad, AlBadri, Ahmed, Handberg, Eileen M., Petersen, John, Pepine, Carl J., Nelson, Michael D., Bairey Merz, C. Noel
Format: Article
Language:English
Subjects:
Circumferential strain
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Circulation
Coronary microvascular disease
Coronary microvascular dysfunction
Female
Heart Ventricles
Humans
Ischemia
Mechanical dysfunction
Myocardial Ischemia - diagnostic imaging
Myocardial Ischemia - epidemiology
Subclinical dysfunction
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - epidemiology
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Summary:Women with ischemia but no obstructive coronary artery disease (INOCA) often have coronary microvascular dysfunction (CMD). Left ventricular (LV) circumferential strain (CS) is often lower in INOCA compared to healthy controls; however, it remains unclear whether CS differs between INOCA women with and without CMD. We hypothesized that CS would be lower in women with CMD, consistent with CMD-induced LV mechanical dysfunction. Cardiac magnetic resonance (cMR) images were examined from women enrolled in the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction Project. CS by feature tracking in INOCA women with CMD, defined as myocardial perfusion reserve index (MPRI)
ISSN:0167-5273
1874-1754
1874-1754
DOI:10.1016/j.ijcard.2020.11.006