Historical and new insights into pathogenesis of type 1 diabetes (2)

Summary In this second and final part of the collection of articles for the Immunology of Diabetes Society review series on insights into pathogenesis of type 1 diabetes, we present two articles. The first of these covers a debate that took place in the Immunology of Diabetes Society meeting in Lond...

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Bibliographic Details
Published in:Clinical and experimental immunology 2021-05, Vol.204 (2), p.165-166
Main Authors: Wong, F. S., Tree, T. I.
Format: Article
Language:English
Subjects:
Autoantigens - immunology
CD4 antigen
CD4-Positive T-Lymphocytes - immunology
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - immunology
Humans
Immunology
Lymphocytes T
Pathogenesis
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Summary:Summary In this second and final part of the collection of articles for the Immunology of Diabetes Society review series on insights into pathogenesis of type 1 diabetes, we present two articles. The first of these covers a debate that took place in the Immunology of Diabetes Society meeting in London 2018, in which five investigators presented a case for specific immune cells/targets to be the ‘Achilles Heel of type 1 diabetes’. The second article presents further insights into the generation of post‐translationally modified peptides. It focuses upon mechanisms and processes that lead to new potentially autoantigenic targets for CD8+ T cells, and complements the review of new hybrid peptide targets for CD4+ T cells in the first part of our series.
ISSN:0009-9104
1365-2249
DOI:10.1111/cei.13597