Effect of a Multifactorial Intervention on Fracture in Patients With Type 2 Diabetes: Subanalysis of the J-DOIT3 Study

Abstract Aims To evaluate the effects of an intensified multifactorial intervention and patient characteristics on the incidence of fractures comorbid with type 2 diabetes. Methods Fracture events were identified and analyzed among adverse events reported in the J-DOIT3 study, a multicenter, open-la...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2021-05, Vol.106 (5), p.e2116-e2128
Main Authors: Sasako, Takayoshi, Ueki, Kohjiro, Miyake, Kana, Okazaki, Yukiko, Takeuchi, Yasuhiro, Ohashi, Yasuo, Noda, Mitsuhiko, Kadowaki, Takashi
Format: Article
Language:English
Subjects:
Analysis
Biomarkers - analysis
Blood cholesterol
Blood Glucose - analysis
Blood pressure
Care and treatment
Chemical industry
Cholesterol
Clinical s
Comorbidity
Dextrose
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - therapy
Diabetes therapy
Female
Follow-Up Studies
Fractures
Fractures, Bone - epidemiology
Fractures, Bone - etiology
Fractures, Bone - metabolism
Fractures, Bone - pathology
Glucose
Glycated Hemoglobin A - analysis
Glycosylated hemoglobin
Herbicides
Humans
Incidence
Japan - epidemiology
Lipids
Low density lipoprotein
Low density lipoproteins
Male
Middle Aged
Osteoporosis
Pesticides industry
Pharmaceutical industry
Pioglitazone
Prognosis
Risk assessment
Risk Factors
Smoking
Type 2 diabetes
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Summary:Abstract Aims To evaluate the effects of an intensified multifactorial intervention and patient characteristics on the incidence of fractures comorbid with type 2 diabetes. Methods Fracture events were identified and analyzed among adverse events reported in the J-DOIT3 study, a multicenter, open-label, randomized, parallel-group trial that was conducted in Japan, in which patients with type 2 diabetes were randomly assigned to receive conventional therapy for glucose, blood pressure, and lipids (targets: HbA1c 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgab013