DNA methylation changes on immune cells in Systemic Lupus Erythematosus

DNA methylation as a process that regulates gene expression is crucial in immune cells biology. Global and gene specific methylation changes have been described in autoimmunity, especially in Systemic Lupus Erythematosus. These changes not only contribute to the understanding of the disease, but als...

Full description

Saved in:
Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2020-04, Vol.53 (3), p.114-121
Main Authors: Hurtado, Carolina, Acevedo Sáenz, Liliana Yazmín, Vásquez Trespalacios, Elsa María, Urrego, Rodrigo, Jenks, Scott, Sanz, Iñaki, Vásquez, Gloria
Format: Article
Language:English
Subjects:
autoimmunity
DNA methylation
Systemic Lupus Erythematosus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:DNA methylation as a process that regulates gene expression is crucial in immune cells biology. Global and gene specific methylation changes have been described in autoimmunity, especially in Systemic Lupus Erythematosus. These changes not only contribute to the understanding of the disease, but also some have been proposed as diagnostic or disease activity biomarkers. The present review compiles the most recent discoveries on this field on each type of immune cells, including specific changes in signalling pathways, genes of interest and its possible applications on diagnosis or treatment.
ISSN:0891-6934
1607-842X
DOI:10.1080/08916934.2020.1722108