Development of Pigmentation-Regulating Agents by Drug Repositioning

Skin color is determined by the processes of melanin synthesis and distribution. Problems in various molecules or signaling pathways involved in melanin synthesis contribute to skin pigmentation defects. Several trials have been conducted on the production of pigmentation-regulating agents, and drug...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2021-04, Vol.22 (8), p.3894
Main Authors: Jeong, Seo-Mi-Gon, Yoon, Tae-Jin
Format: Article
Language:English
Subjects:
Dermatology
Drugs
Experiments
FDA approval
Gene expression
Kinases
Melanin
Phosphorylation
Pigmentation
Proteins
Review
Skin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Skin color is determined by the processes of melanin synthesis and distribution. Problems in various molecules or signaling pathways involved in melanin synthesis contribute to skin pigmentation defects. Several trials have been conducted on the production of pigmentation-regulating agents, and drug repositioning has emerged as a modern technique to identify new uses for existing drugs. Our research team has researched substances or drugs associated with pigmentation control and, as a result, nilotinib, sorafenib, and ICG-001 have been found to promote pigmentation, while 5-iodotubercidin inhibits pigmentation. Therefore, these substances or medications were suggested as potential therapeutics for pigmentation disorders by drug repositioning.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22083894