Secular Trends in Ablation Therapy for Graves' Disease: An Analysis of a 15-Year Experience at a Tertiary Hospital in South Korea

Ablation therapy, such as radioactive iodine (RAI) therapy or thyroidectomy, is generally used as the second-line treatment for Graves' disease (GD) in Asia. This study investigated changes in the clinical characteristics and outcomes of ablation therapies for GD over 15 years. Patients who und...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-04, Vol.10 (8), p.1629
Main Authors: Kim, Min Joo, Kim, Ye An, Cho, Sun Wook, Kim, Su-Jin, Lee, Kyu Eun, Park, Young Joo, Park, Do Joon, Cho, Bo Youn
Format: Article
Language:English
Subjects:
Ablation
Age
Antibodies
Clinical medicine
Hepatitis
Hospitals
Remission (Medicine)
Thyroid cancer
Thyroidectomy
Trends
Urticaria
Womens health
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Summary:Ablation therapy, such as radioactive iodine (RAI) therapy or thyroidectomy, is generally used as the second-line treatment for Graves' disease (GD) in Asia. This study investigated changes in the clinical characteristics and outcomes of ablation therapies for GD over 15 years. Patients who underwent ablation therapy between 2001 and 2015 at a single tertiary hospital were included. Among the 10,991 GD patients treated over this 15-year period, 1357 (12.3%) underwent ablation therapy, and the most common reason was intractable GD. The proportion of patients who underwent any type of ablation therapy significantly decreased from 9.0% (2001-2005) to 7.7% (2011-2015). However, the proportion of patients who underwent surgery significantly increased from 1.1% (2001-2005) to 2.4% (2011-2015), and the proportion of patients who received ablation therapy due to suspected thyroid cancer increased from 5% to 13% over time. With a median follow-up duration of 6.2 years, remission was achieved in 86% and 98% of patients in the RAI and surgery groups, respectively, and these rates remained stable over time. In conclusion, although the proportion of patients who underwent ablation therapy for GD decreased during 15 years, the proportion of those who underwent surgery increased in association with the increased rate of suspected thyroid cancers.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10081629