Predictors of Single Bronchodilation Treatment Response for COPD: An Observational Study with the Trace Database Cohort

Chronic obstructive pulmonary disease (COPD) patients constitute a heterogeneous population in terms of treatment response. Our objective was to identify possible predictive factors of response to treatment with single bronchodilation monotherapy in patients diagnosed with COPD. The Time-based Regis...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-04, Vol.10 (8), p.1708
Main Authors: Carrasco Hernández, Laura, Caballero Eraso, Candela, Ruiz-Duque, Borja, Abad Arranz, María, Márquez Martín, Eduardo, Calero Acuña, Carmen, Lopez-Campos, Jose Luis
Format: Article
Language:English
Subjects:
Bronchodilators
Chronic obstructive pulmonary disease
Clinical medicine
Clinical trials
Dyspnea
Gender
Medical research
Observational studies
Patients
Population
Sociodemographics
Statistical analysis
Variables
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Summary:Chronic obstructive pulmonary disease (COPD) patients constitute a heterogeneous population in terms of treatment response. Our objective was to identify possible predictive factors of response to treatment with single bronchodilation monotherapy in patients diagnosed with COPD. The Time-based Register and Analysis of COPD Endpoints (TRACE; clinicaltrials.gov NCT03485690) is a prospective cohort of COPD patients who have been attending annual visits since 2012. Patients who were kept on a single bronchodilator during the first year of follow-up were selected. The responders were defined according to all of the following variables: any improvement in morning post-dose forced expiratory volume in 1 s or deterioration
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10081708