The Association between Migraine and Abdominal Aortic Aneurysms: A Nationwide Population-Based Cohort Study

Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients wi...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-04, Vol.18 (8), p.4389
Main Authors: Lin, Jou-Yu, Tung, Che-Se, Wang, Jen-Chun, Chien, Wu-Chien, Chung, Chi-Hsiang, Lin, Chih-Yuan, Tsai, Shih-Hung
Format: Article
Language:English
Subjects:
Age
Aorta
Aortic Aneurysm, Abdominal - epidemiology
Aortic aneurysms
Cardiovascular disease
Cardiovascular diseases
Chronic obstructive pulmonary disease
Cohort analysis
Cohort Studies
Diabetes
Epidemiology
Headache
Health insurance
Humans
Hypertension
Migraine
Migraine Disorders - complications
Migraine Disorders - epidemiology
Molecular modelling
Nonsteroidal anti-inflammatory drugs
Patients
Population
Population studies
Population-based studies
Regression analysis
Retrospective Studies
Risk analysis
Risk Factors
Stroke
Taiwan - epidemiology
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Summary:Previous studies have indicated that patients with migraine have a higher prevalence of risk factors known to be associated with cardiovascular diseases. There are also shared epidemiology and molecular mechanisms between migraine and abdominal aortic aneurysm (AAA). We hypothesized that patients with migraine could have an increased risk of AAA. To test this hypothesis, we used the National Health Insurance Research Database (NHIRD) to evaluate whether associations exist between migraine and AAA. The data for this nationwide population-based retrospective cohort study were obtained from the NHIRD in Taiwan. The assessed study outcome was the cumulative incidence of AAA in patients with migraine during a 15-year follow-up period. Among the 1,936,512 patients from the NHIRD, 53,668 (2.77%) patients were identified as having been diagnosed with migraine. The patients with migraine had a significantly higher cumulative risk of 3.558 of developing an AAA 5 years after the index date compared with the patients without migraine. At the end of the 15-year follow-up period, a significantly higher incidence of AAA (0.98%) was observed in the patients with migraine than in those without migraine (0.24%). We revealed an association between the development of migraine and AAA.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18084389