Granulomatosis with Polyangiitis with Ocular Manifestations

Granulomatosis with polyangiitis (GPA) is a granulomatous-necrotic systemic vasculitis with a lesion of predominantly the upper and lower respiratory tracts at the onset of the disease (vasculitis, accompanied by granulomatous inflammation), and subsequently renal (glomerulonephritis). In addition,...

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Bibliographic Details
Published in:Case reports in ophthalmology 2021-01, Vol.12 (1), p.98-104
Main Authors: Orazbekov, Lukpan, Issergepova, Botagoz, Assainova, Makpal, Ruslanuly, Kairat
Format: Article
Language:English
Subjects:
Abscesses
Antibiotics
Biopsy
Case Report
Case reports
Cornea
corneal ulcer
Edema
granulomatosis with polyangiitis
Inflammatory diseases
necrotizing scleritis
Rheumatoid arthritis
Sinusitis
Steroids
Systemic diseases
Tomography
Ulcers
Vein & artery diseases
wegener’s granulomatosis
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Summary:Granulomatosis with polyangiitis (GPA) is a granulomatous-necrotic systemic vasculitis with a lesion of predominantly the upper and lower respiratory tracts at the onset of the disease (vasculitis, accompanied by granulomatous inflammation), and subsequently renal (glomerulonephritis). In addition, GPA may manifest as inflammation of small arteries and veins. Despite many years of study of this disease, the etiology of GPA remains unknown. The present case is about a 47-year-old female, who had been suffering from necrotizing scleritis, corneal ulcer, and secondary glaucoma in both eyes for 3 months, and she was treated with anti-inflammatory and antimicrobial therapy that showed no effect; the patient’s general condition became worse. In the second week of treatment, multiple abscess ruptures exposed the sclera. Sampling of the affected conjunctival tissue and positive HLA B8 haplotype and ANCA (PR3-ANCA) testings make it clear that GPA was the main reason of necrotizing scleritis with inflammation. The targeted treatment of the underlying disease allows to stabilize an inflammation of corneal and scleral lesions.
ISSN:1663-2699
1663-2699
DOI:10.1159/000510959