Respiratory RNA Viruses: How to Be Prepared for an Encounter with New Pandemic Virus Strains

The characteristics of the biology of influenza viruses and coronavirus that determine the implementation of the infectious process are presented. With provision for pathogenesis of infection possible effects of serine proteinase inhibitors, heparin, and inhibitors of heparan sulfate receptors in th...

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Bibliographic Details
Published in:Biology bulletin reviews 2021, Vol.11 (2), p.154-171
Main Authors: Chepur, S. V., Pluzhnikov, N. N., Chubar, O. V., Bakulina, L. S., Litvinenko, I. V., Makarov, V. A., Gogolevsky, A. S., Myasnikov, V. A., Myasnikova, I. A., Al-Shehadat, R. I.
Format: Article
Language:English
Subjects:
Antioxidants
Antiviral agents
Biochemistry
Biomedical and Life Sciences
Cell Biology
Chelating agents
Chloroquine
Contamination
Coronaviruses
Ecology
Glycosylation
Heparan sulfate
Heparin
Inflammation
Influenza
Interferon
Life Sciences
Metals
Pandemics
pH effects
Proteinase
RNA viruses
Serine
Serine proteinase
Serine proteinase inhibitors
Toxicity
Valency
Viruses
Zoology
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Summary:The characteristics of the biology of influenza viruses and coronavirus that determine the implementation of the infectious process are presented. With provision for pathogenesis of infection possible effects of serine proteinase inhibitors, heparin, and inhibitors of heparan sulfate receptors in the prevention of cell contamination by viruses are examined. It has been determined that chelators of metals of variable valency and antioxidants should be used for the reduction of replicative activity of viruses and anti-inflammatory therapy. The possibility of a pH-dependent impairment of glycosylation of cellular and viral proteins was traced for chloroquine and its derivatives. The use of low-toxicity drugs as part of adjunct therapy increases the effectiveness of synthetic antiviral drugs and interferons and ensures the safety of baseline therapy.
ISSN:2079-0864
2079-0872
DOI:10.1134/S207908642102002X