Risk of cancer in patients with recurrent aphthous stomatitis in Korea: A nationwide population-based study

The relationship between recurrent aphthous stomatitis (RAS), a common mucosal lesion, and cancer has not been demonstrated. This study investigated the risk for developing cancer in patients with RAS, based on data from Korea's National Health Insurance Sharing Service (NHISS). Nationwide popu...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-04, Vol.100 (16), p.e25628-e25628
Main Authors: Kwon, Ki Jin, Jeong, Su Jin, Eun, Young-Gyu, Oh, In Hwan, Lee, Young Chan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Case-Control Studies
Child
Databases, Factual
Female
Humans
Incidence
Male
Middle Aged
National Health Programs
Neoplasms - epidemiology
Neoplasms - etiology
Observational Study
Propensity Score
Proportional Hazards Models
Recurrence
Republic of Korea - epidemiology
Risk Assessment
Risk Factors
Stomatitis, Aphthous - complications
Stomatitis, Aphthous - epidemiology
Young Adult
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Summary:The relationship between recurrent aphthous stomatitis (RAS), a common mucosal lesion, and cancer has not been demonstrated. This study investigated the risk for developing cancer in patients with RAS, based on data from Korea's National Health Insurance Sharing Service (NHISS). Nationwide population-based cohort data from 2005 to 2009 provided by the NHISS was used. The group diagnosed with RAS for 5 years and an undiagnosed control group were constructed through 1:1 propensity score matching (PSM). The experimental design compared the incidence rate of a cancer diagnosis from 2010 to 2015 between these 2 groups. After identifying 13,808 people that met our inclusion criterion from a 1 million cohort group, 13,808 controls were included in the study through PSM. Among all cancers, pancreatic cancer had an adjusted hazard ratio of 1.26 (95% confidence interval: 1.01-1.57, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000025628