Utility of Endoscopic Ultrasound with Bronchoscope-guided Fine-needle Aspiration for Detecting Driver Oncogenes in Non-small-cell Lung Cancer during Emergency Situations: Case Series

Since it is difficult to obtain tumor tissue via airway observation for lung cancer patients with a poor respiratory condition, endoscopic ultrasound with bronchoscope-guided fine-needle-aspiration (EUS-B-FNA), a transesophageal procedure, is effective for such patients. We herein report three patie...

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Bibliographic Details
Published in:Internal Medicine 2021/04/01, Vol.60(7), pp.1061-1065
Main Authors: Nakashima, Koki, Demura, Yoshiki, Oi, Masahiro, Tabata, Mio, Tada, Toshihiko, Shiozaki, Kohei, Akai, Masaya, Ishizuka, Tamotsu
Format: Article
Language:English
Subjects:
ALK
Bronchoscopes
Bronchoscopy
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - genetics
Case Report
driver oncogene
EGFR
Emergency medical care
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Endoscopy
EUS-B-FNA
Humans
Internal medicine
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - genetics
Non-small cell lung carcinoma
non-small-cell lung cancer
Oncogenes
Oncogenes - genetics
oncologic emergency
Protein-tyrosine kinase
Ultrasonic imaging
Ultrasound
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Summary:Since it is difficult to obtain tumor tissue via airway observation for lung cancer patients with a poor respiratory condition, endoscopic ultrasound with bronchoscope-guided fine-needle-aspiration (EUS-B-FNA), a transesophageal procedure, is effective for such patients. We herein report three patients with driver oncogenes taken to the emergency department because of lung cancer-related symptoms. EUS-B-FNA was performed because of the patients' poor respiratory conditions to detect driver oncogenes. The general conditions improved, and the patients achieved a long-term survival with tyrosine kinase inhibitors. Our findings suggest that EUS-B-FNA should be considered to detect driver oncogenes in lung cancer patients despite poor respiratory conditions in emergency departments.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.5594-20