Functional Connectome in Parkinson’s Disease and Parkinsonism

Purpose of Review There has been an exponential growth in functional connectomics research in neurodegenerative disorders. This review summarizes the recent findings and limitations of the field in Parkinson’s disease (PD) and atypical parkinsonian syndromes. Recent Findings Increasingly more sophis...

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Bibliographic Details
Published in:Current neurology and neuroscience reports 2021-06, Vol.21 (6), p.24-24, Article 24
Main Author: Tinaz, Sule
Format: Article
Language:English
Subjects:
Basal ganglia
Brain diseases
Central nervous system diseases
Connectome
Humans
Medicine
Medicine & Public Health
Movement disorders
Multiple System Atrophy
Neural networks
Neurodegenerative diseases
Neuroimaging (N. Pavese
Neurological disorders
Neurology
Neurosciences
Parkinson Disease - diagnostic imaging
Parkinson's disease
Parkinsonian Disorders - diagnostic imaging
Phenotypes
Reproducibility of Results
Section Editor
Supranuclear Palsy, Progressive
Topical Collection on Neuroimaging
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Summary:Purpose of Review There has been an exponential growth in functional connectomics research in neurodegenerative disorders. This review summarizes the recent findings and limitations of the field in Parkinson’s disease (PD) and atypical parkinsonian syndromes. Recent Findings Increasingly more sophisticated methods ranging from seed-based to network and whole-brain dynamic functional connectivity have been used. Results regarding the disruption in the functional connectome vary considerably based on disease severity and phenotypes, and treatment status in PD. Non-motor symptoms of PD also link to the dysfunction in heterogeneous networks. Studies in atypical parkinsonian syndromes are relatively scarce. Summary An important clinical goal of functional connectomics in neurodegenerative disorders is to establish the presence of pathology, track disease progression, predict outcomes, and monitor treatment response. The obstacles of reliability and reproducibility in the field need to be addressed to improve the potential of the functional connectome as a biomarker for these purposes in PD and atypical parkinsonian syndromes.
ISSN:1528-4042
1534-6293
DOI:10.1007/s11910-021-01111-4