Ongoing pregnancy and healthy live births following very short ovarian stimulation of incidentally observed big antral follicles in oligoamenorrheic patients with extremely decreased ovarian reserve

In the present case series our aim is to present seven patients with extremely decreased ovarian reserve and oligomenorrhea, conceived with in vitro fertilization following a very short ovarian stimulation of incidentally detected big antral follicles. The study included women pursuing in vitro fert...

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Bibliographic Details
Published in:JBRA assisted reproduction 2021, Vol.25 (2), p.324-327
Main Authors: Turan, Volkan, Sonmezer, Meltem, Sonmezer, Murat
Format: Article
Language:English
Subjects:
Age
Births
Case Report
Chemotherapy
Embryos
Female
Fertilization in Vitro
Follicles
Humans
In vitro fertilization
Infertility
Live Birth
Menstruation
Ovarian Follicle - diagnostic imaging
Ovarian Reserve
Ovaries
Ovulation
Ovulation Induction
Patients
Pregnancy
Pregnancy complications
Sperm Injections, Intracytoplasmic
Ultrasonic imaging
Womens health
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Summary:In the present case series our aim is to present seven patients with extremely decreased ovarian reserve and oligomenorrhea, conceived with in vitro fertilization following a very short ovarian stimulation of incidentally detected big antral follicles. The study included women pursuing in vitro fertilization due to premature ovarian failure risk. When an incidental growing antral follicle was detected under ultrasound, immediate ovarian stimulation was initiated if the blood estradiol, luteinizing hormone and progesterone levels were correlated. Serum anti-Mullerian hormone measurements of all patients were consistent with extremely diminished ovarian reserve (ranged between 0.01 and 0.09ng/ml) and FSH levels varied between 13-104IU/l. The mean stimulation length ranged between 2-4 days. A total of 8 oocytes were retrieved; 6 MII, 1 GV and 1 degenerated. All 6 MII oocytes were fertilized with intracytoplasmic sperm injection. Two patients conceived after fresh embryo transfer, whereas the one conceived following frozen thawed embryo transfer. The ongoing pregnancy rate was 50% per transfer, and two of them resulted in a healthy live birth. In conclusion, close monitoring of oligoamenorrheic infertile patients who are at high risk of imminent ovarian failure using ultrasound and blood hormone levels is very important. Albeit low, the possibility of having a healthy pregnancy following "a very short ovarian stimulation" in such a specific patient group is emphasized.
ISSN:1518-0557
1517-5693
1518-0557
DOI:10.5935/1518-0557.20200095