Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study

Antihypertensive drugs have been reported as both promotors and suppressors of cancers and this relationship has been known for several decades. We examined a large‐scale prospective cohort study in Japan to assess the relationship between long‐term antihypertensive drug use, for 10 y, and carcinoge...

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Bibliographic Details
Published in:Cancer science 2021-05, Vol.112 (5), p.1997-2005
Main Authors: Matsui, Satoshi, Sobue, Tomotaka, Zha, Ling, Kitamura, Tetsuhisa, Sawada, Norie, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Alcohol
Angiogenesis
Antihypertensive Agents - adverse effects
Antihypertensive Agents - therapeutic use
Antihypertensives
Blood pressure
Blood Pressure Determination
Breast cancer
Cancer
cancer risk
Carcinogenesis
cohort
Cohort Studies
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - chemically induced
Drug abuse
Drug use
Enzymes
Female
Gastric cancer
Humans
Japan
Kidney cancer
Kidney Neoplasms - chemically induced
Kidneys
Liver cancer
long‐term drug use
Lung cancer
Male
Middle Aged
Neoplasms - chemically induced
Neoplasms - epidemiology
Original
Proportional Hazards Models
Prospective Studies
prospective study
Prostate
Public health
Questionnaires
Sex Factors
Smoking
Time Factors
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Summary:Antihypertensive drugs have been reported as both promotors and suppressors of cancers and this relationship has been known for several decades. We examined a large‐scale prospective cohort study in Japan to assess the relationship between long‐term antihypertensive drug use, for 10 y, and carcinogenesis. We divided participants into 4 categories according to the period of antihypertensive drug use, and calculated the hazard ratios (HRs), 95% confidence intervals (CIs), and P trends using the Cox proportional hazard model. In all cancers, there was a significant difference in the medication period and the adjusted HR, as well as a significant difference in the P trend. Furthermore, more than 10 y use of antihypertensive drugs significantly increased the adjusted HR in colorectal cancer (multivariable HR: 1.18, 95% CI: 1.01‐1.37 in the >10 y use group; P for trend = .033) and renal cancer (multivariable HR: 3.76, 95% CI: 2.32‐6.10 in the 5‐10 y use group; multivariable HR: 2.14, 95% CI: 1.29‐3.56 in the >10 y use group; P for trend 
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.14870