Neutrophils: mediating TelOxidation and senescence

Cellular senescence is considered to be a major driver of aging, yet the mechanisms explaining the accumulation of senescent cells during life time remain unclear. In this issue, Lagnado et al  (2021) show that neutrophils can trigger the senescence of neighboring cells by transmitting reactive oxyg...

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Bibliographic Details
Published in:The EMBO journal 2021-05, Vol.40 (9), p.e108164-n/a
Main Authors: Jacome Burbano, Maria Sol, Cherfils‐Vicini, Julien, Gilson, Eric
Format: Article
Language:English
Subjects:
Aging
EMBO06
EMBO19
EMBO24
Homeostasis
Leukocytes (neutrophilic)
Life Sciences
Neutrophils
News & Views
Oxidative stress
Reactive oxygen species
Senescence
Telomeres
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Summary:Cellular senescence is considered to be a major driver of aging, yet the mechanisms explaining the accumulation of senescent cells during life time remain unclear. In this issue, Lagnado et al  (2021) show that neutrophils can trigger the senescence of neighboring cells by transmitting reactive oxygen species (ROS), which they normally produce to fight pathogens. The main genomic targets of the neutrophil‐mediated ROS damage are telomeres, supporting an intimate interplay between telomere homeostasis and oxidative stress in senescence and consequently aging. Graphical Abstract Recent work reports a paracrine role for neutrophils in the induction of cellular senescence and tissue damage.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2021108164