Performance of the Abbott ID NOW rapid SARS-CoV-2 amplification assay in relation to nasopharyngeal viral RNA loads

•Calibration of the Xpert with viral stock dilutions was linear and reproducible.•Overall Xpert/ID-NOW positive agreement = 70% and negative agreement = 99.6%.•Sensitivity of ID-NOW for Xpert N2 CT ≤ 37 (viral loads ≥ 945 copies/mL) was 100%.•Sensitivity of ID-NOW for Xpert N2 for N2 CT > 37 was...

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Bibliographic Details
Published in:Journal of clinical virology 2021-07, Vol.140, p.104843-104843, Article 104843
Main Authors: Sepulveda, Jorge L., Abdulbaki, Rami, Sands, Zachary, Codoy, Maria, Mendoza, Salome, Isaacson, Nancy, Kochar, Olga, Keiser, John, Haile-Mariam, Tenagne, Meltzer, Andrew C., Mores, Christopher N., Sepulveda, Antonia R.
Format: Article
Language:English
Subjects:
Abbott ID NOW
Clinical Laboratory Techniques
COVID-19
COVID-19 - diagnosis
COVID-19 Nucleic Acid Testing
Humans
Laboratory utilization
Nasopharynx - virology
Rapid testing
RNA, Viral - isolation & purification
SARS-CoV-2
SARS-CoV-2 - isolation & purification
Sensitivity
Sensitivity and Specificity
Viral Load
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Summary:•Calibration of the Xpert with viral stock dilutions was linear and reproducible.•Overall Xpert/ID-NOW positive agreement = 70% and negative agreement = 99.6%.•Sensitivity of ID-NOW for Xpert N2 CT ≤ 37 (viral loads ≥ 945 copies/mL) was 100%.•Sensitivity of ID-NOW for Xpert N2 for N2 CT > 37 was only 37.7%.
ISSN:1386-6532
1873-5967
1873-5967
DOI:10.1016/j.jcv.2021.104843