Vaccine adjuvants: Current challenges and future approaches

For humans, companion animals, and food producing animals, vaccination has been touted as the most successful medical intervention for the prevention of disease in the twentieth century. However, vaccination is not without problems. With the development of new and less reactogenic vaccine antigens,...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2009-04, Vol.98 (4), p.1278-1316
Main Authors: Wilson-Welder, Jennifer H., Torres, Maria P., Kipper, Matt J., Mallapragada, Surya K., Wannemuehler, Michael J., Narasimhan, Balaji
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - adverse effects
Adjuvants, Immunologic - therapeutic use
alum
Animals
Antibody Formation - drug effects
biodegradable polymers
Biological and medical sciences
Communicable Disease Control - methods
Communicable Disease Control - trends
Communicable Diseases - drug therapy
Communicable Diseases - immunology
controlled release/delivery
General pharmacology
Humans
Immunity, Cellular - drug effects
Immunity, Innate - drug effects
immunology
liposomes
Medical sciences
mucosal immunization
Mycobacterium
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
polymeric biomaterials
TLR ligands
vaccine adjuvants
vaccines
Vaccines - administration & dosage
Vaccines - adverse effects
Vaccines - immunology
Vaccines - therapeutic use
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Summary:For humans, companion animals, and food producing animals, vaccination has been touted as the most successful medical intervention for the prevention of disease in the twentieth century. However, vaccination is not without problems. With the development of new and less reactogenic vaccine antigens, which take advantage of molecular recombinant technologies, also comes the need for more effective adjuvants that will facilitate the induction of adaptive immune responses. Furthermore, current vaccine adjuvants are successful at generating humoral or antibody mediated protection but many diseases currently plaguing humans and animals, such as tuberculosis and malaria, require cell mediated immunity for adequate protection. A comprehensive discussion is presented of current vaccine adjuvants, their effects on the induction of immune responses, and vaccine adjuvants that have shown promise in recent literature. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:1278–1316, 2009
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.21523