Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China

Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in coronavirus disease 2019 (COVID-19) patients have been reported. However, the clinical outcome and pathogenesis remain unclear. In this study, we recruited 43 laboratory-confirmed COVID-19...

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Bibliographic Details
Published in:Science China. Life sciences 2021-12, Vol.64 (12), p.2129-2143
Main Authors: Li, Zhengtu, Li, Yinhu, Sun, Ruilin, Li, Shaoqiang, Chen, Lingdan, Zhan, Yangqing, Xie, Mingzhou, Yang, Jiasheng, Wang, Yanqun, Zhu, Airu, Gu, Guoping, Yu, Le, Li, Shuaicheng, Liu, Tingting, Chen, Zhaoming, Jian, Wenhua, Jiang, Qian, Su, Xiaofen, Gu, Weili, Chen, Liyan, Cheng, Jing, Zhao, Jincun, Lu, Wenju, Zheng, Jinping, Li, Shiyue, Zhong, Nanshan, Ye, Feng
Format: Article
Language:English
Subjects:
Adult
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Biomedical and Life Sciences
China - epidemiology
Computed tomography
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - pathology
COVID-19 - virology
Female
Gene Expression Profiling
Genome, Viral - genetics
Hospitalization
Humans
Interleukin 1
Life Sciences
Longitudinal Studies
Lung - pathology
Male
Middle Aged
Mutation
Pathogenesis
Patients
Polymerase chain reaction
Research Paper
Ribonucleic acid
RNA
RNA, Viral - genetics
RNA, Viral - metabolism
SARS-CoV-2 - genetics
SARS-CoV-2 - isolation & purification
SARS-CoV-2 - pathogenicity
SARS-CoV-2 - physiology
Severe acute respiratory syndrome coronavirus 2
Time Factors
Virus Replication
Virus Shedding
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Summary:Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in coronavirus disease 2019 (COVID-19) patients have been reported. However, the clinical outcome and pathogenesis remain unclear. In this study, we recruited 43 laboratory-confirmed COVID-19 patients. We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients ( P
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-020-1921-5