Neuromuscular Electrical Stimulation and High-Protein Supplementation After Subarachnoid Hemorrhage: A Single-Center Phase 2 Randomized Clinical Trial

• Published in: Neurocritical care 2021-08, Vol.35 (1), p.46-55
• Main Authors: Badjatia, Neeraj, Sanchez, Stephanie, Judd, Gabriella, Hausladen, Rachel, Hering, David, Motta, Melissa, Parikh, Gunjan, Chang, Wendy, Morris, Nicholas, Simard, J. Marc, Sorkin, John, Wittenberg, George F., Ryan, Alice S.
• Format: Article
• Language: English
• Subjects: Aneurysms; Body mass index; Critical Care Medicine; Data collection; Dietary Supplements; Electric Stimulation; Electric Stimulation Therapy; Exercise; Female; Hemorrhage; Humans; Intensive; Internal Medicine; Intervention; Male; Medical imaging; Medicine; Medicine & Public Health; Musculoskeletal system; Neurology; Neuromuscular electrical stimulation; Neurosurgery; Nitrogen; Nutrition; Original Work; Parenteral nutrition; Patients; Physical fitness; Proteins; Quality of life; Recovery of Function; Standard of care; Subarachnoid Hemorrhage - therapy
• ISSN: 1541-6933; 1556-0961
• DOI: 10.1007/s12028-020-01138-4

Introduction Aneurysmal subarachnoid hemorrhage (SAH) survivors live with long-term residual physical and cognitive disability. We studied whether neuromuscular electrical stimulation (NMES) and high-protein supplementation (HPRO) in the first 2 weeks after SAH could preserve neuromotor and cognitive function as compared to standard of care (SOC) for nutrition and mobilization. Methods SAH subjects with a Hunt Hess (HH) grade > 1,modified Fisher score > 1 and BMI  3). Median duration of interventions was 12 days (range 9–14) with completion of 98% of NMES sessions and 83% of goal HPRO, and no reported serious adverse events. There was no difference in caloric intake between groups, but HPRO + NMES group received more protein (1.5 ± 0.5 g/kg/d v 0.9 ± 0.4 g/kg/d, P