Association of obstructive sleep apnea/hypopnea syndrome with glaucomatous optic neuropathy and ocular blood flow

• Published in: Experimental and therapeutic medicine 2021-06, Vol.21 (6), p.657-657, Article 657
• Main Authors: Dalianis, Georgios, Trivli, Alexandra, Limnopoulou, Aliki, Stavrakis, Andreas, Terzidou, Chryssa, Detorakis, Efstathios T, Kozobolis, Vassilios, Labiris, Georgios
• Format: Article
• Language: English
• Subjects: Blood flow; Complications and side effects; Diabetes; Disease; Females; Glaucoma; Health aspects; Hypertension; Normal distribution; Optic nerve; Oxygen saturation; Patients; Regression analysis; Risk factors; Sleep apnea; Sleep apnea syndromes; Statistical analysis; Veins & arteries
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2021.10089

The present study aimed to investigate the prevalence of glaucomatous optic neuropathy in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). In total, 83 subjects (45 cases of severe OSAHS and 38 controls) underwent polysomnographic assessment and were evaluated for the severity of the disease using the Apnea-Hypopnea index. A detailed ophthalmologic exam was then performed, including measurement of the intraocular pressure (IOP) with a Goldmann applanation tonometer and Pascal dynamic contour tonometer (DCT), recording of the ocular pulse amplitude measured by the Pascal DCT, standard automated perimetry and retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness evaluation using optical coherence tomography. Ocular blood flow was assessed using color Doppler imaging (CDI) and ophthalmic artery indices were evaluated, including peak systolic blood velocity, end diastolic blood velocity and resistivity index (RI). There was a significant difference in the mean IOP between controls (11.03±3.85 mmHg) and cases of severe OSAHS (18.06±3.39 mmHg) when the IOP was measured by DCT (P