Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance)

Abstract Background Obesity and inactivity are associated with increased risk of cancer-related and overall mortality in breast cancer, but there are few data in metastatic disease. Methods Cancer and Leukemia Group B 40502 was a randomized trial of first-line taxane-based chemotherapy for patients...

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Bibliographic Details
Published in:JNCI cancer spectrum 2021-06, Vol.5 (3)
Main Authors: Ligibel, Jennifer A, Huebner, Luke, Rugo, Hope S, Burstein, Harold J, Toppmeyer, Debra L, Anders, Carey K, Ma, Cynthia, Barry, William T, Suman, Vera, Carey, Lisa A, Partridge, Ann H, Hudis, Clifford A, Winer, Eric P
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents, Immunological - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bevacizumab - administration & dosage
Bevacizumab - therapeutic use
Body Height
Body Mass Index
Body Weight
Breast Neoplasms - chemistry
Breast Neoplasms - drug therapy
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Epothilones - administration & dosage
Epothilones - therapeutic use
Exercise - statistics & numerical data
Female
Humans
Middle Aged
Obesity - epidemiology
Paclitaxel - administration & dosage
Paclitaxel - therapeutic use
Progression-Free Survival
Proportional Hazards Models
Treatment Outcome
Young Adult
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Summary:Abstract Background Obesity and inactivity are associated with increased risk of cancer-related and overall mortality in breast cancer, but there are few data in metastatic disease. Methods Cancer and Leukemia Group B 40502 was a randomized trial of first-line taxane-based chemotherapy for patients with metastatic breast cancer. Height and weight were collected at enrollment. After 299 patients enrolled, the study was amended to assess recreational physical activity (PA) at enrollment using the Nurses’ Health Study Exercise Questionnaire. Associations with progression-free survival (PFS) and overall survival (OS) were evaluated using stratified Cox modeling (strata included hormone receptor status, prior taxane, bevacizumab use, and treatment arm). All statistical tests were 2-sided. Results A total of 799 patients were enrolled, and at the time of data lock, median follow-up was 60 months. At enrollment, median age was 56.7 years, 73.1% of participants had hormone receptor–positive cancers, 42.6% had obesity, and 47.6% engaged in less than 3 metabolic equivalents of task (MET) hours of PA per week (
ISSN:2515-5091
2515-5091
DOI:10.1093/jncics/pkab025