Suprachoroidal haemorrhage (SCH) drainage using suprachoroidal tissue plasminogen activator (t-PA) after complicated cataract extraction (two-staged procedure): early intervention could mean better vision

Therapeutic recombinant t-PA (rt-PA), first trialled in humans in 19841; benefits from superior half-life, specificity to fibrin and resistance to inactivators compared with its native counterpart.2 In ophthalmology, rt-PA can help clear submacular haemorrhage, often in combination with other treatm...

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Bibliographic Details
Published in:BMJ case reports 2021-05, Vol.14 (5), p.e241705
Main Authors: Akram, Haseeb, Dowlut, Mohammad Samir, Chandra, Aman
Format: Article
Language:English
Subjects:
Bats
Case reports
Cataract Extraction
Cataracts
Choroid Hemorrhage
Drainage
Eye surgery
Hemorrhage
Humans
Images In
Lens, Crystalline
Ostomy
Sutures
Tissue Plasminogen Activator - therapeutic use
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Summary:Therapeutic recombinant t-PA (rt-PA), first trialled in humans in 19841; benefits from superior half-life, specificity to fibrin and resistance to inactivators compared with its native counterpart.2 In ophthalmology, rt-PA can help clear submacular haemorrhage, often in combination with other treatment modalities.3 To the authors’ knowledge this is the second case report concerning rt-PA use for suprachoroidal haemorrhage (SCH) drainage following cataract surgery.4 An 85-year-old woman was referred following left eye cataract surgery complicated by massive SCH. Learning points Tissue plasminogen activator can help to drain suprachoroidal haemorrhage earlier, possibly better visual outcome. Tissue plasminogen activator-assisted vitrectomy in the early treatment of acute massive suprachoroidal hemorrhage complicating cataract surgery.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2021-241705