2021 Advocacy Statements for the Role of ⁹⁹ᵐTc-Pyrophosphate Scintigraphy in the Diagnosis of Transthyretin Cardiac Amyloidosis: A Report of the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China

Transthyretin cardiac amyloidosis (ATTR-CM) is an increasingly recognized cause of heart failure with preserved ejection fraction. Favorable prognosis depends on early diagnosis and correct treatment strategy. Among patients for whom there is a high clinical suspicion of cardiac amyloidosis, ⁹⁹ᵐTc-l...

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Bibliographic Details
Published in:Acta Cardiologica Sinica 2021-05, Vol.37 (3), p.221-231
Main Authors: Huang, Yih-Hwen, Lin, Yen-Hung, Yen, Ruoh-Fang, Hou, Charles Jia-Yin, Wang, Shan-Ying, Tsai, Shih-Chuan, Ho, Kung-Chu, Lin, Ming-Hsien, Tsao, Chin-Ho, Chang, Chih-Yung, Huang, Jin-Long, Cheng, Mei-Fang, Wu, Yen-Wen
Format: Article
Language:chi ; eng
Subjects:
Cardiac amyloidosis
Cardiomyopathy
Consensus
Heart failure
MEDLINE
SCIE
Scintigraphy
Scopus
Transthyretin
ᵐTc-pyrophosphate (PYP)
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Summary:Transthyretin cardiac amyloidosis (ATTR-CM) is an increasingly recognized cause of heart failure with preserved ejection fraction. Favorable prognosis depends on early diagnosis and correct treatment strategy. Among patients for whom there is a high clinical suspicion of cardiac amyloidosis, ⁹⁹ᵐTc-labeled bone avid scintigraphy including ⁹⁹ᵐTc-pyrophosphate (PYP) scintigraphy may be of diagnostic and prognostic importance. Various international guidelines support the non-biopsy diagnosis of ATTR-CM using ⁹⁹ᵐTc-PYP scintigraphy, yet emphasize the gap in standardization of acquisition and imaging analysis protocols, as well as the appropriateness of its clinical use. Therefore, a joint expert consensus has been reached by the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China, to advocate for the application of ⁹⁹ᵐTc-PYP scintigraphy in the diagnosis of ATTR-CM. This article aims to highlight the recommendations on image acquisition, qualitative and quantitative assessments of cardiac ⁹⁹ᵐTc-PYP uptake, and diagnostic algorithms. We hope the implementation of these recommendations in Taiwan will facilitate the process and enhance the diagnostic rate of ATTR-CM.
ISSN:1011-6842
DOI:10.6515/ACS.202105_37(3).20210420A