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Upsurge of Conjugate Vaccine Serotype 4 Invasive Pneumococcal Disease Clusters Among Adults Experiencing Homelessness in California, Colorado, and New Mexico
Abstract After 7-valent pneumococcal conjugate vaccine introduction in the United States in 2000, invasive pneumococcal disease (IPD) due to serotype 4 greatly decreased in children and adults. Starting in 2013, serotype 4 IPD incidence increased among adults within 3 of 10 Active Bacterial Core sur...
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| Published in: | The Journal of infectious diseases 2021-04, Vol.223 (7), p.1241-1249 |
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| cites | cdi_FETCH-LOGICAL-c452t-8e8f1ab0dc2394f35a69745197bf23ae34add7f7d1179f138158cf988dccf1693 |
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| container_issue | 7 |
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| container_title | The Journal of infectious diseases |
| container_volume | 223 |
| creator | Beall, Bernard Walker, Hollis Tran, Theresa Li, Zhongya Varghese, Jasmine McGee, Lesley Li, Yuan Metcalf, Benjamin J Gierke, Ryan Mosites, Emily Chochua, Sopio Pilishvili, Tamara |
| description | Abstract
After 7-valent pneumococcal conjugate vaccine introduction in the United States in 2000, invasive pneumococcal disease (IPD) due to serotype 4 greatly decreased in children and adults. Starting in 2013, serotype 4 IPD incidence increased among adults within 3 of 10 Active Bacterial Core surveillance sites. Of 325 serotype 4 cases among adults in 2010–2018, 36% were persons experiencing homelessness (PEH); incidence of serotype 4 IPD among PEH was 100–300 times higher than in the general population within these 3 areas. Genome sequencing for isolates recovered 2015–2018 (n = 246), revealed that increases in serotype 4 IPD were driven by lineages ST10172, ST244, and ST695. Within each lineage, clusters of near-identical isolates indicated close temporal relatedness. Increases in serotype 4 IPD were limited to Colorado, California, and New Mexico, with highest increases among PEH, who were at increased risk for exposure to and infections caused by these strains.
Multiple genetic lineages of invasive vaccine serotype 4 pneumococci have increased incidences within 3 of 10 Active Bacterial Core surveillance sites. These lineages are composed of highly related isolate clusters and are disproportionally associated with persons experiencing homelessness. |
| doi_str_mv | 10.1093/infdis/jiaa501 |
| format | article |
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After 7-valent pneumococcal conjugate vaccine introduction in the United States in 2000, invasive pneumococcal disease (IPD) due to serotype 4 greatly decreased in children and adults. Starting in 2013, serotype 4 IPD incidence increased among adults within 3 of 10 Active Bacterial Core surveillance sites. Of 325 serotype 4 cases among adults in 2010–2018, 36% were persons experiencing homelessness (PEH); incidence of serotype 4 IPD among PEH was 100–300 times higher than in the general population within these 3 areas. Genome sequencing for isolates recovered 2015–2018 (n = 246), revealed that increases in serotype 4 IPD were driven by lineages ST10172, ST244, and ST695. Within each lineage, clusters of near-identical isolates indicated close temporal relatedness. Increases in serotype 4 IPD were limited to Colorado, California, and New Mexico, with highest increases among PEH, who were at increased risk for exposure to and infections caused by these strains.
Multiple genetic lineages of invasive vaccine serotype 4 pneumococci have increased incidences within 3 of 10 Active Bacterial Core surveillance sites. These lineages are composed of highly related isolate clusters and are disproportionally associated with persons experiencing homelessness.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiaa501</identifier><identifier>PMID: 32798216</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; California - epidemiology ; Colorado - epidemiology ; Epidemiology ; Genomes ; Homeless people ; Homeless Persons ; Humans ; Incidence ; Lung diseases ; New Mexico - epidemiology ; Pneumococcal Infections - epidemiology ; Pneumococcal Infections - microbiology ; Pneumococcal Vaccines ; Serogroup ; Streptococcus infections ; Streptococcus pneumoniae - classification ; Vaccines ; Vaccines, Conjugate</subject><ispartof>The Journal of infectious diseases, 2021-04, Vol.223 (7), p.1241-1249</ispartof><rights>Published by Oxford University Press for the Infectious Diseases Society of America 2020. 2020</rights><rights>Published by Oxford University Press for the Infectious Diseases Society of America 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-8e8f1ab0dc2394f35a69745197bf23ae34add7f7d1179f138158cf988dccf1693</citedby><cites>FETCH-LOGICAL-c452t-8e8f1ab0dc2394f35a69745197bf23ae34add7f7d1179f138158cf988dccf1693</cites><orcidid>0000-0001-8222-7353</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32798216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beall, Bernard</creatorcontrib><creatorcontrib>Walker, Hollis</creatorcontrib><creatorcontrib>Tran, Theresa</creatorcontrib><creatorcontrib>Li, Zhongya</creatorcontrib><creatorcontrib>Varghese, Jasmine</creatorcontrib><creatorcontrib>McGee, Lesley</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Metcalf, Benjamin J</creatorcontrib><creatorcontrib>Gierke, Ryan</creatorcontrib><creatorcontrib>Mosites, Emily</creatorcontrib><creatorcontrib>Chochua, Sopio</creatorcontrib><creatorcontrib>Pilishvili, Tamara</creatorcontrib><title>Upsurge of Conjugate Vaccine Serotype 4 Invasive Pneumococcal Disease Clusters Among Adults Experiencing Homelessness in California, Colorado, and New Mexico</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
After 7-valent pneumococcal conjugate vaccine introduction in the United States in 2000, invasive pneumococcal disease (IPD) due to serotype 4 greatly decreased in children and adults. Starting in 2013, serotype 4 IPD incidence increased among adults within 3 of 10 Active Bacterial Core surveillance sites. Of 325 serotype 4 cases among adults in 2010–2018, 36% were persons experiencing homelessness (PEH); incidence of serotype 4 IPD among PEH was 100–300 times higher than in the general population within these 3 areas. Genome sequencing for isolates recovered 2015–2018 (n = 246), revealed that increases in serotype 4 IPD were driven by lineages ST10172, ST244, and ST695. Within each lineage, clusters of near-identical isolates indicated close temporal relatedness. Increases in serotype 4 IPD were limited to Colorado, California, and New Mexico, with highest increases among PEH, who were at increased risk for exposure to and infections caused by these strains.
Multiple genetic lineages of invasive vaccine serotype 4 pneumococci have increased incidences within 3 of 10 Active Bacterial Core surveillance sites. These lineages are composed of highly related isolate clusters and are disproportionally associated with persons experiencing homelessness.</description><subject>Adult</subject><subject>California - epidemiology</subject><subject>Colorado - epidemiology</subject><subject>Epidemiology</subject><subject>Genomes</subject><subject>Homeless people</subject><subject>Homeless Persons</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung diseases</subject><subject>New Mexico - epidemiology</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Infections - microbiology</subject><subject>Pneumococcal Vaccines</subject><subject>Serogroup</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Vaccines</subject><subject>Vaccines, Conjugate</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkctu1DAUQC0EotPCliWyxAakpvUrib2pNAqFVioPCcrW8jjXg0eJHexk2n4M_0qqGSpgw8LywsfHvjoIvaDkhBLFT31wrc-nG29MSegjtKAlr4uqovwxWhDCWEGlUgfoMOcNIUTwqn6KDjirlWS0WqCf10Oe0hpwdLiJYTOtzQj4m7HWB8BfIMXxbgAs8GXYmuy3gD8HmPpoo7Wmw299BpMBN92UR0gZL_sY1njZTt2Y8fntAMlDmF1rfBF76CDnMC_sA25M511MwZvj-eUuJtPGY2xCiz_CDf4At97GZ-iJM12G5_v9CF2_O__aXBRXn95fNsurwoqSjYUE6ahZkdYyroTjpalULUqq6pVj3AAXpm1rV7eU1spRLmkprVNSttY6Wil-hM523mFa9dBaCGMynR6S702609F4_fdJ8N_1Om61pERSei94vRek-GOCPOreZwtdZwLEKWsmuBB1JYWc0Vf_oJs4pTCPp5kq53CEUzZTJzvKpphzAvfwGUr0fXm9K6_35ecLL_8c4QH_nXoG3uyAOA3_k_0CNdm9Xw</recordid><startdate>20210408</startdate><enddate>20210408</enddate><creator>Beall, Bernard</creator><creator>Walker, Hollis</creator><creator>Tran, Theresa</creator><creator>Li, Zhongya</creator><creator>Varghese, Jasmine</creator><creator>McGee, Lesley</creator><creator>Li, Yuan</creator><creator>Metcalf, Benjamin J</creator><creator>Gierke, Ryan</creator><creator>Mosites, Emily</creator><creator>Chochua, Sopio</creator><creator>Pilishvili, Tamara</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8222-7353</orcidid></search><sort><creationdate>20210408</creationdate><title>Upsurge of Conjugate Vaccine Serotype 4 Invasive Pneumococcal Disease Clusters Among Adults Experiencing Homelessness in California, Colorado, and New Mexico</title><author>Beall, Bernard ; Walker, Hollis ; Tran, Theresa ; Li, Zhongya ; Varghese, Jasmine ; McGee, Lesley ; Li, Yuan ; Metcalf, Benjamin J ; Gierke, Ryan ; Mosites, Emily ; Chochua, Sopio ; Pilishvili, Tamara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-8e8f1ab0dc2394f35a69745197bf23ae34add7f7d1179f138158cf988dccf1693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>California - epidemiology</topic><topic>Colorado - epidemiology</topic><topic>Epidemiology</topic><topic>Genomes</topic><topic>Homeless people</topic><topic>Homeless Persons</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung diseases</topic><topic>New Mexico - epidemiology</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Pneumococcal Infections - microbiology</topic><topic>Pneumococcal Vaccines</topic><topic>Serogroup</topic><topic>Streptococcus infections</topic><topic>Streptococcus pneumoniae - classification</topic><topic>Vaccines</topic><topic>Vaccines, Conjugate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beall, Bernard</creatorcontrib><creatorcontrib>Walker, Hollis</creatorcontrib><creatorcontrib>Tran, Theresa</creatorcontrib><creatorcontrib>Li, Zhongya</creatorcontrib><creatorcontrib>Varghese, Jasmine</creatorcontrib><creatorcontrib>McGee, Lesley</creatorcontrib><creatorcontrib>Li, Yuan</creatorcontrib><creatorcontrib>Metcalf, Benjamin J</creatorcontrib><creatorcontrib>Gierke, Ryan</creatorcontrib><creatorcontrib>Mosites, Emily</creatorcontrib><creatorcontrib>Chochua, Sopio</creatorcontrib><creatorcontrib>Pilishvili, Tamara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beall, Bernard</au><au>Walker, Hollis</au><au>Tran, Theresa</au><au>Li, Zhongya</au><au>Varghese, Jasmine</au><au>McGee, Lesley</au><au>Li, Yuan</au><au>Metcalf, Benjamin J</au><au>Gierke, Ryan</au><au>Mosites, Emily</au><au>Chochua, Sopio</au><au>Pilishvili, Tamara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upsurge of Conjugate Vaccine Serotype 4 Invasive Pneumococcal Disease Clusters Among Adults Experiencing Homelessness in California, Colorado, and New Mexico</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2021-04-08</date><risdate>2021</risdate><volume>223</volume><issue>7</issue><spage>1241</spage><epage>1249</epage><pages>1241-1249</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
After 7-valent pneumococcal conjugate vaccine introduction in the United States in 2000, invasive pneumococcal disease (IPD) due to serotype 4 greatly decreased in children and adults. Starting in 2013, serotype 4 IPD incidence increased among adults within 3 of 10 Active Bacterial Core surveillance sites. Of 325 serotype 4 cases among adults in 2010–2018, 36% were persons experiencing homelessness (PEH); incidence of serotype 4 IPD among PEH was 100–300 times higher than in the general population within these 3 areas. Genome sequencing for isolates recovered 2015–2018 (n = 246), revealed that increases in serotype 4 IPD were driven by lineages ST10172, ST244, and ST695. Within each lineage, clusters of near-identical isolates indicated close temporal relatedness. Increases in serotype 4 IPD were limited to Colorado, California, and New Mexico, with highest increases among PEH, who were at increased risk for exposure to and infections caused by these strains.
Multiple genetic lineages of invasive vaccine serotype 4 pneumococci have increased incidences within 3 of 10 Active Bacterial Core surveillance sites. These lineages are composed of highly related isolate clusters and are disproportionally associated with persons experiencing homelessness.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32798216</pmid><doi>10.1093/infdis/jiaa501</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8222-7353</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2021-04, Vol.223 (7), p.1241-1249 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Adult California - epidemiology Colorado - epidemiology Epidemiology Genomes Homeless people Homeless Persons Humans Incidence Lung diseases New Mexico - epidemiology Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumococcal Vaccines Serogroup Streptococcus infections Streptococcus pneumoniae - classification Vaccines Vaccines, Conjugate |
| title | Upsurge of Conjugate Vaccine Serotype 4 Invasive Pneumococcal Disease Clusters Among Adults Experiencing Homelessness in California, Colorado, and New Mexico |
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