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TLR2 and TLR4 Gene Expression in Peripheral Monocytes in Nondiabetic Hypertensive Patients: The Effect of Intensive Blood Pressure–Lowering

J Clin Hypertens (Greenwich). 2012; 14:330–335. ©2012 Wiley Periodicals, Inc. The activation of innate immune receptors, such as Toll‐like receptors (TLRs), participates in the pathogenesis of cardiovascular diseases. The authors evaluated TLR2 and TLR4 gene expression in the peripheral monocytes of...

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Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2012-05, Vol.14 (5), p.330-335
Main Authors: Marketou, Maria E., Kontaraki, Joanna E., Zacharis, Evangelos A., Kochiadakis, George E., Giaouzaki, Aikaterini, Chlouverakis, Gregory, Vardas, Panos E.
Format: Article
Language:English
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Summary:J Clin Hypertens (Greenwich). 2012; 14:330–335. ©2012 Wiley Periodicals, Inc. The activation of innate immune receptors, such as Toll‐like receptors (TLRs), participates in the pathogenesis of cardiovascular diseases. The authors evaluated TLR2 and TLR4 gene expression in the peripheral monocytes of nondiabetic hypertensive patients compared with normotensive individuals and investigated the effect of intensive systolic blood pressure (SBP)–lowering. Included were 43 nondiabetic hypertensive patients with essential hypertension who were randomly assigned to an intensive treatment arm, with an SBP target of
ISSN:1524-6175
1751-7176
DOI:10.1111/j.1751-7176.2012.00620.x