Left Ventricular Mass Reduction in Type 1 Diabetic Patients With Nephropathy

Left ventricular hypertrophy regression was postulated more likely to occur in diabetic patients when renal function was preserved. Seventeen type 1 diabetic patients followed for 12 months while receiving protocol‐driven glycemic and blood pressure control had baseline and 12‐month echocardiography...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2005-03, Vol.7 (3), p.159-164
Main Authors: Weinrauch, Larry A., Burger, Andrew, Gleason, Ray E., Lee, Annette T., D'Elia, John A.
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Glucose - metabolism
Blood Pressure
Cardiovascular Diseases - prevention & control
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - physiopathology
Diabetic Nephropathies - complications
Diabetic Nephropathies - physiopathology
Disease Progression
Female
Follow-Up Studies
Humans
Hypertrophy, Left Ventricular - etiology
Hypertrophy, Left Ventricular - physiopathology
Kidney - physiopathology
Kidney Function Tests
Male
Middle Aged
Original Papers
Sex Factors
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Summary:Left ventricular hypertrophy regression was postulated more likely to occur in diabetic patients when renal function was preserved. Seventeen type 1 diabetic patients followed for 12 months while receiving protocol‐driven glycemic and blood pressure control had baseline and 12‐month echocardiography. Despite identical treatment resulting in similar blood pressures, patients with better renal function (below the group mean, serum creatinine ≤1.7 mg/dL) demonstrated reduction in left ventricular mass and septal thickness as well as increase in left ventricular fractional fiber shortening not observed in those with worse renal function (above the group mean, serum creatinine >1.7 mg/dL). This latter group also did not experience the improvement in glycemic control observed in those with better renal function. Regression of left ventricular mass and functional improvement can be accomplished with improved glycemic control. In the presence of renal dysfunction, however, efforts to control glycemia and cardiac work are suboptimal. Aggressive glycemic and blood pressure targets to reduce cardiovascular morbidity in this high‐risk population should be studied.
ISSN:1524-6175
1751-7176
DOI:10.1111/j.1524-6175.2005.04307.x