Attenuation of Autonomic Nervous System Functions in Hypertensive Patients at Rest and During Orthostatic Stimulation

The effect of age on autonomic nervous system was assessed at rest and while standing using systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate, and power spectral analysis of the time duration between 2 consecutive R waves of an electrocardiogram (RR) interval variability,...

Full description

Saved in:
Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2008-02, Vol.10 (2), p.97-104
Main Authors: Karas, Maria, Larochelle, Pierre, LeBlanc, Robert A., Dubé, Bruno, Nadeau, Reginald, Champlain, Jacques de
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Autonomic Nervous System - physiopathology
Blood Pressure
Electrocardiography
Epinephrine - blood
Female
Heart Rate
Humans
Hypertension - blood
Hypertension - physiopathology
Male
Middle Aged
Nordefrin - blood
Original Papers
Receptors, Adrenergic, beta - physiology
Severity of Illness Index
Supine Position
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of age on autonomic nervous system was assessed at rest and while standing using systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate, and power spectral analysis of the time duration between 2 consecutive R waves of an electrocardiogram (RR) interval variability, as well as on plasma norepinephrine and epinephrine levels in mild to moderate hypertensive patients (DBP, 90–110 mm Hg). Patients younger than 60 years (n=57) and older than 60 years (n=32), were evaluated after a 3‐ to 4‐week placebo period. Plasma catecholamines were measured in the supine position at rest and after 10 minutes of standing. Power spectral analysis of the RR interval variability was performed in each condition using the high‐frequency (HF) band (0.15–0.4 Hz) as an index of parasympathetic activity and the low‐frequency (LF) band (0.05–0.15 Hz) and LF‐HF ratio to estimate sympathetic activity. The total power was calculated as the sum of LF and HF power. supine SBP was significantly higher in older patients (P
ISSN:1524-6175
1751-7176
DOI:10.1111/j.1751-7176.2008.07324.x