Hobnail variant of papillary thyroid carcinoma: a systematic review and meta-analysis

Objective The hobnail variant of papillary thyroid carcinoma (HVPTC) has emerged as a rare and aggressive variant of papillary thyroid carcinoma (PTC). We aim to determine the prevalence and clinicopathologic factors of HVPTC. Methods A systematic review of the literature for studies examining HVPTC...

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Bibliographic Details
Published in:Endocrine 2021-04, Vol.72 (1), p.27-39
Main Authors: Donaldson, Lane B., Yan, Flora, Morgan, Patrick F., Kaczmar, John M., Fernandes, Jyotika K., Nguyen, Shaun A., Jester, Rachel L., Day, Terry A.
Format: Article
Language:English
Subjects:
Diabetes
Endocrine Reports from the COVID-19 Frontline
Endocrinology
Humanities and Social Sciences
Internal Medicine
Literature reviews
Lymph nodes
Lymphatic system
Medicine
Medicine & Public Health
Meta-analysis
Metastases
Metastasis
Morphology
multidisciplinary
Papillary thyroid carcinoma
Patients
Review
Science
Systematic review
Thyroid
Thyroid cancer
Tumors
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Summary:Objective The hobnail variant of papillary thyroid carcinoma (HVPTC) has emerged as a rare and aggressive variant of papillary thyroid carcinoma (PTC). We aim to determine the prevalence and clinicopathologic factors of HVPTC. Methods A systematic review of the literature for studies examining HVPTC was performed. Four databases (PubMed, Scopus, OVID, Cochrane library) were queried from inception of databases through March 20th, 2020. Results Sixteen studies with 124 cases of HVPTC were included. The mean age for all patients was 52.3 years. HVPTC had a prevalence of 1.08% out of all PTC cases, with a mean tumor size of 3.1 cm. In 62% and 50% of cases, lymphovascular invasion and extrathyroidal extension were present, respectively. Follow-up data, with a mean of 49.9 months, revealed a 66% rate of lymph node metastasis and 23% rate of distant metastasis. Tumors with ≥30% hobnail morphology had a 2.6-fold increased odds of developing lymph node metastasis compared with
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02505-z