Von Willebrand factor collagen-binding capacity predicts in-hospital mortality in COVID-19 patients: insight from VWF/ADAMTS13 ratio imbalance

Background Microthrombosis is a hallmark of COVID-19. We previously described von willebrand factor (VWF) and their high molecular weight multimers (HMWMs) as potential trigger of microthrombosis. Objectives Investigate VWF activity with collagen-binding assay and ADAMTS13 in COVID-19. Methods and r...

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Bibliographic Details
Published in:Angiogenesis (London) 2021-08, Vol.24 (3), p.407-411
Main Authors: Philippe, Aurélien, Gendron, Nicolas, Bory, Olivier, Beauvais, Agathe, Mirault, Tristan, Planquette, Benjamin, Sanchez, Olivier, Diehl, Jean-Luc, Chocron, Richard, Smadja, David M.
Format: Article
Language:English
Subjects:
ADAMTS13 Protein - blood
Aged
Binding
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
C-reactive protein
Cancer Research
Cardiology
Cell Biology
Collagen
Collagen (type I)
Collagen - metabolism
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - mortality
Cross-Sectional Studies
Dimers
Female
Hospital Mortality
Humans
Kaplan-Meier Estimate
Letter
Male
Middle Aged
Molecular weight
Mortality
Oncology
Ophthalmology
Overflow
Pandemics
Paris - epidemiology
Patients
Plasma levels
Proportional Hazards Models
Protein Binding
SARS-CoV-2
Severity of Illness Index
Statistical models
Von Willebrand factor
von Willebrand Factor - metabolism
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Summary:Background Microthrombosis is a hallmark of COVID-19. We previously described von willebrand factor (VWF) and their high molecular weight multimers (HMWMs) as potential trigger of microthrombosis. Objectives Investigate VWF activity with collagen-binding assay and ADAMTS13 in COVID-19. Methods and results Our study enrolled 77 hospitalized COVID-19 patients including 37 suffering from a non-critical form and 40 with critical form. Plasma levels of VWF collagen-binding ability (VWF:CB) and ADAMTS13 activity (ADAMTS13:Act) were measured in the first 48 hours following admission. VWF:CB was increased in critical (631% IQR [460–704]) patients compared to non-critical patients (259% [235–330], p  
ISSN:0969-6970
1573-7209
DOI:10.1007/s10456-021-09789-3