Morphological, genetic and clinical correlations in infantile hemangiomas and their mimics

Infantile hemangiomas (IHs) are the most frequent pediatric benign vascular tumors, with a reported incidence of 5% to 10%. They have self-limiting evolution pattern divided into a growth phase in the first 12 months and a regression one, that may take up to 10 years. Occasionally, hemangiomas might...

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Bibliographic Details
Published in:Romanian journal of morphology and embryology 2020-07, Vol.61 (3), p.687-695
Main Authors: Luca, Alina Costina, Miron, Ingrith Crenguţa, Trandafir, Laura Mihaela, Cojocaru, Elena, Pădureţ, Ioana Alexandra, Trandafirescu, Mioara Florentina, Iordache, Alin Constantin, Ţarcă, Elena
Format: Article
Language:English
Subjects:
Review
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Summary:Infantile hemangiomas (IHs) are the most frequent pediatric benign vascular tumors, with a reported incidence of 5% to 10%. They have self-limiting evolution pattern divided into a growth phase in the first 12 months and a regression one, that may take up to 10 years. Occasionally, hemangiomas might lead to local or systemic complications, depending on their morphological characteristics. The first line of treatment is β -blockers, such as Propranolol, Timolol, Nadolol, administered either locally or systemically. Newer therapeutic strategies involving laser therapy and angiotensin-converting enzyme inhibitors are being studied, while older treatment modalities like corticosteroids, Imiquimod, Vincristine, Bleomycin and Interferon- α have become second line therapy options. Before establishing the appropriate treatment, clinical, histological, and imaging investigations are required.
ISSN:1220-0522
2066-8279
DOI:10.47162/RJME.61.3.07