Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-c][1,2,4]Triazin-4-ols

An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1- с ][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.

Saved in:
Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2021-04, Vol.57 (4), p.473-478
Main Authors: Drokin, Roman A., Tiufiakov, Dmitrii V., Voinkov, Egor K., Slepukhin, Pavel A., Ulomsky, Evgeny N., Esaulkova, Yana L., Volobueva, Alexandrina S., Lantseva, Kristina S., Misyurina, Mariya A., Zarubaev, Vladimir V., Rusinov, Vladimir L.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Influenza
Ketones
Laninamivir
Methods
Organic Chemistry
Pharmacy
Substitution reactions
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1- с ][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-021-02926-2