Development of Pathological Diagnosis Support System Using Micro-computed Tomography

In pathological diagnosis, the cutting position of pathological materials is subjectively determined by pathologists. This leads to a low cutting accuracy, which in turn may lead to incorrect diagnoses. In this study, we developed a system that supports the determination of the cutting position by v...

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Bibliographic Details
Published in:ACTA HISTOCHEMICA ET CYTOCHEMICA 2021/04/28, Vol.54(2), pp.49-56
Main Authors: Hayakawa, Tomonari, Teramoto, Atsushi, Kiriyama, Yuka, Tsukamoto, Tetsuya, Yamada, Ayumi, Saito, Kuniaki, Fujita, Hiroshi
Format: Article
Language:English
Subjects:
Computed tomography
Computer programs
Diagnosis
diagnosis support
micro-computed tomography
pathological diagnosis
Technical Advancement
Ultrastructure
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Summary:In pathological diagnosis, the cutting position of pathological materials is subjectively determined by pathologists. This leads to a low cutting accuracy, which in turn may lead to incorrect diagnoses. In this study, we developed a system that supports the determination of the cutting position by visualizing and analyzing the internal structure of pathological material using micro-computed tomography (CT) before cutting. This system consists of a dedicated micro-CT and cutting support software. The micro-CT system has a fixture for fixing the target, enabling the scanning of easily deformable pathological materials. In the cutting support software, a function that interactively selects the extraction plane while displaying the volume rendering image and outputs a pseudo-histological image was implemented. Our results confirmed that the pseudo-histological image showed the fine structure inside the organ and that the latter image was highly consistent with the pathological image.
ISSN:0044-5991
1347-5800
DOI:10.1267/ahc.20-00033