Genomic epidemiology of nontoxigenic Corynebacterium diphtheriae from King County, Washington State, USA between July 2018 and May 2019

Between July 2018 and May 2019, was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic biovar mitis. Whole-genome sequencing confirmed...

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Published in:Microbial genomics 2020-12, Vol.6 (12)
Main Authors: Xiaoli, Lingzi, Benoliel, Eileen, Peng, Yanhui, Aneke, Janessa, Cassiday, Pamela K, Kay, Meagan, McKeirnan, Shelly, Duchin, Jeffery S, Kawakami, Vance, Lindquist, Scott, Acosta, Anna M, DeBolt, Chas, Tondella, Maria Lucia, Weigand, Michael R
Format: Article
Language:English
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Outbreak Report
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Summary:Between July 2018 and May 2019, was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Compared to publicly available genomic data, these WA isolates formed a discrete cluster with SNP variation consistent with previously reported outbreaks. Virulence-related gene content variation within the highly related WA cluster isolates was also observed. These results indicated that genome characterization can readily support epidemiology of nontoxigenic .
ISSN:2057-5858
2057-5858
DOI:10.1099/mgen.0.000467