Lupin protein isolate improves insulin sensitivity and steatohepatitis in vivo and modulates the expression of the Fasn, Gys2, and Gsk3b genes

Although studies on lupin protein isolate (LPI) have indicated the presence of a preventive effect on insulin resistance (IR) and lipid disturbances, their influence on established pathological traits has received little attention. Here, we evaluated the in vivo effects of LPI on IR and steatohepati...

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Published in:Food science & nutrition 2021-05, Vol.9 (5), p.2549-2560
Main Authors: Soto‐Luna, Irma Catalina, García‐López, Pedro Macedonio, Vargas‐Guerrero, Belinda, Guzmán, Tereso Jovany, Domínguez‐Rosales, José Alfredo, Gurrola‐Díaz, Carmen Magdalena
Format: Article
Language:English
Subjects:
Carbohydrate metabolism
Carbohydrates
Cholesterol
Diabetes
Diet
Enzymes
Fatty acids
fatty liver
Gene expression
Genes
Glucose
High fat diet
Hyperglycemia
Insulin
Insulin resistance
Laboratory animals
Legumes
Lipid metabolism
Lipids
Lipogenesis
Liver
Metabolism
Original Research
Proteins
Seeds
Sensitivity
Soybeans
Triglycerides
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Summary:Although studies on lupin protein isolate (LPI) have indicated the presence of a preventive effect on insulin resistance (IR) and lipid disturbances, their influence on established pathological traits has received little attention. Here, we evaluated the in vivo effects of LPI on IR and steatohepatitis as well as its influence on genes involved in lipid and carbohydrate metabolism. We first induced IR and steatohepatitis in rats by maintaining them on a high‐fat diet for 5 weeks. Thereafter, we administered LPI to the rats daily for 3 weeks. LPI improved insulin sensitivity (AUC: 6,777 ± 232 vs. 4,971 ± 379, p 
ISSN:2048-7177
2048-7177
DOI:10.1002/fsn3.2206