Resistin: An inflammatory cytokine with multi-faceted roles in cancer

Systemic and organ-confined inflammation has been associated with cancer development and progression. Resistin, initially described as an adipocyte-derived cytokine in mice, is mostly expressed by the macrophages in humans. It has potent pro-inflammatory properties, and its elevated serum levels are...

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Published in:Biochimica et biophysica acta. Reviews on cancer 2020-12, Vol.1874 (2), p.188419-188419, Article 188419
Main Authors: Sudan, Sarabjeet Kour, Deshmukh, Sachin Kumar, Poosarla, Teja, Holliday, Nicolette Paolaungthong, Dyess, Donna Lynn, Singh, Ajay Pratap, Singh, Seema
Format: Article
Language:English
Subjects:
Cancer
Cytokine
Disease Progression
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
Humans
Inflammation
Neoplasms - blood
Neoplasms - immunology
Resistin
Resistin - blood
Resistin - chemistry
Resistin - metabolism
Signal Transduction
Tumor Microenvironment
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Summary:Systemic and organ-confined inflammation has been associated with cancer development and progression. Resistin, initially described as an adipocyte-derived cytokine in mice, is mostly expressed by the macrophages in humans. It has potent pro-inflammatory properties, and its elevated serum levels are detected in cancer patients. Aberrant expression of resistin receptors is also reported in several malignancies and associated with aggressive clinicopathological features. Several lines of evidence demonstrate that resistin, acting through its different receptors, promotes tumor growth, metastasis, and chemoresistance by influencing a variety of cellular phenotypes as well as by modulating the tumor microenvironment. Racially disparate expression of resistin has also attracted much interest, considering prevalent cancer health disparities. This review discusses the aberrant expression of resistin and its receptors, its diverse downstream signaling and impact on tumor growth, metastasis, angiogenesis, and therapy resistance to support its clinical exploitation in biomarker and therapeutic development. •Inflammation is intricately linked with cancer either as a cause or a consequence.•Resistin is a pro-inflammatory cytokine whose serum levels are elevated in cancer patients.•Aberrant expression of resistin receptors is also reported in cancer and associated with disease aggressiveness.•Resistin signaling plays multiple roles in cancer development and could be exploited for cancer prevention and therapy.
ISSN:0304-419X
1879-2561
DOI:10.1016/j.bbcan.2020.188419