Cardiovascular magnetic resonance stress and rest T1-mapping using regadenoson for detection of ischemic heart disease compared to healthy controls

Adenosine stress T1-mapping on cardiovascular magnetic resonance (CMR) can differentiate between normal, ischemic, infarcted, and remote myocardial tissue classes without the need for contrast agents. Regadenoson, a selective coronary vasodilator, is often used in stress perfusion imaging when adeno...

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Bibliographic Details
Published in:International journal of cardiology 2021-06, Vol.333, p.239-245
Main Authors: Burrage, Matthew K., Shanmuganathan, Mayooran, Masi, Ambra, Hann, Evan, Zhang, Qiang, Popescu, Iulia A., Soundarajan, Rajkumar, Leal Pelado, Joana, Chow, Kelvin, Neubauer, Stefan, Piechnik, Stefan K., Ferreira, Vanessa M.
Format: Article
Language:English
Subjects:
Cardiovascular magnetic resonance
Contrast Media
Coronary artery disease
Coronary Circulation
Humans
Magnetic Resonance Imaging
Magnetic Resonance Imaging, Cine
Magnetic Resonance Spectroscopy
Myocardial Ischemia - diagnostic imaging
Myocardial Perfusion Imaging
Myocardium
Predictive Value of Tests
Purines
Pyrazoles
Regadenoson
ShMOLLI
T1-mapping
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Summary:Adenosine stress T1-mapping on cardiovascular magnetic resonance (CMR) can differentiate between normal, ischemic, infarcted, and remote myocardial tissue classes without the need for contrast agents. Regadenoson, a selective coronary vasodilator, is often used in stress perfusion imaging when adenosine is contra-indicated, and has advantages in ease of administration, safety profile, and clinical workflow. We aimed to characterize the regadenoson stress T1-mapping response in healthy individuals, and to investigate its ability to differentiate between myocardial tissue classes in patients with coronary artery disease (CAD). Eleven healthy controls and 25 patients with CAD underwent regadenoson stress perfusion CMR, as well as rest and stress ShMOLLI T1-mapping. Native T1 values and stress T1 reactivity were derived for normal myocardium in healthy controls and for different myocardial tissue classes in patients with CAD. Healthy controls had normal myocardial native T1 values at rest (931 ± 22 ms) with significant global regadenoson stress T1 reactivity (δT1 = 8.2 ± 0.8% relative to baseline; p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2021.03.010