Brain Tumor Imaging in Clinical Trials

There are substantial challenges in the radiologic evaluation of tumor size during clinical trials, and it is important for neuroradiologists to have a firm understanding of these issues. This review will examine measurement approaches, response criteria, selection of lesions for measurement, techni...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2008-03, Vol.29 (3), p.419-424
Main Authors: Henson, J.W, Ulmer, S, Harris, G.J
Format: Article
Language:English
Subjects:
Algorithms
Biological and medical sciences
Brain Neoplasms - diagnosis
Clinical Trials as Topic
Diagnostic Imaging - methods
Fundamental and applied biological sciences. Psychology
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Nervous system
Personality. Affectivity
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Review
Sexuality. Sexual behavior
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Description
Summary:There are substantial challenges in the radiologic evaluation of tumor size during clinical trials, and it is important for neuroradiologists to have a firm understanding of these issues. This review will examine measurement approaches, response criteria, selection of lesions for measurement, technical imaging considerations, interval between tumor measurements and response confirmation, and validity of imaging as a measure of efficacy.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A0963